Patents by Inventor Duane D. Miller

Duane D. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for treatment of cancer
    Patent number: 9447049
    Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: September 20, 2016
    Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Wei Li, Min Xiao, James Dalton, Sunjoo Ahn, Duane D. Miller, Jianjuan Chen, Jin Wang
  • Estrogen receptor ligands and methods of use thereof
    Patent number: 9409856
    Abstract: The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBA compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including, inter alia, prevention and treatment of hormone-related diseases, cancers, inflammation, osteoporosis, peripheral vascular disease, reducing circulating lipid levels, and cardiovascular disease.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: August 9, 2016
    Assignee: Gtx, Inc.
    Inventors: James T. Dalton, Christina Herring, Duane D. Miller, Seoung-Soo Hong, Yali He, Michael L. Mohler, Ramesh Narayanan, Zhongzhi Wu
  • SELECTIVE ANDROGEN RECEPTOR MODULATOR AND METHODS OF USE THEREOF
    Publication number: 20160166530
    Abstract: This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia, a muscle wasting disease and/or disorder such as Duchenne muscular dystrophy or Becker muscular dystrophy.
    Type: Application
    Filed: December 8, 2015
    Publication date: June 16, 2016
    Inventors: JAMES T. DALTON, DUANE D. MILLER
  • SARMS AND METHOD OF USE THEREOF
    Publication number: 20160158185
    Abstract: This invention is directed to substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder such as Duchenne muscular dystrophy or Becker muscular dystrophy.
    Type: Application
    Filed: December 8, 2015
    Publication date: June 9, 2016
    Inventors: James T. Dalton, Duane D. Miller
  • Compounds for treatment of cancer
    Patent number: 9334242
    Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: May 10, 2016
    Assignees: GTX, INC., UNIVERSITY OF TENNESSEE
    Inventors: Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. Dalton, Duane D. Miller, Charles Duke, Sunjoo Ahn
  • SUBSTITUTED ACYLANILIDES AND METHODS OF USE THEREOF
    Publication number: 20160089356
    Abstract: This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder such as muscular dystrophies including Duchenne muscular dystrophy and Becker muscular dystrophy.
    Type: Application
    Filed: December 8, 2015
    Publication date: March 31, 2016
    Inventors: James T. Dalton, Duane D. MILLER
  • SARMs and method of use thereof
    Patent number: 9278914
    Abstract: This invention is directed to a feed composition and method of affecting the carcass composition by increasing the lean mass, reducing the fat mass, and/or reducing the percent fat mass comprising SARM compounds.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: March 8, 2016
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Jeffrey D. Kearbey
  • ESTROGEN RECEPTOR LIGANDS AND METHODS OF USE THEREOF
    Publication number: 20160031797
    Abstract: The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBA compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including, inter alia, prevention and treatment of hormone-related diseases, cancers, inflammation, osteoporosis, peripheral vascular disease, reducing circulating lipid levels, and cardiovascular disease.
    Type: Application
    Filed: June 8, 2015
    Publication date: February 4, 2016
    Inventors: James T. DALTON, Christina Herring, Duane D. MILLER, Seoung-Soo HONG, Yali HE, Michael L. MOHLER, Ramesh NARAYANAN, Zhongzhi WU
  • COMPOUNDS FOR TREATMENT OF CANCER
    Publication number: 20160015688
    Abstract: The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g. trametinib, RO5068760), in combination with anti-tubulin compounds of the invention or other known tubulin inhibitors, and using such compositions for treating cancer such as melanoma, drug-resistant cancer, and cancer metastasis.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 21, 2016
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Jin WANG, Jianjun CHEN, Duane D. MILLER, Wei LI
  • Compounds with increased specificity for the treatment of glioma
    Patent number: 9187449
    Abstract: Disclosed are compounds for the treatment of cancer. Compounds disclosed herein are particularly effective for the selective inhibition of glioma cells.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: November 17, 2015
    Assignee: The University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Shivaputra Appanna Patil, Renukadevi Patil, Terreia Jones, Amira Ahmed, Likeselam Asres, Charles Ryan Yates, Eldon Geisert
  • Nuclear receptor binding agents
    Patent number: 9078888
    Abstract: The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBAs are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, inflammatory diseases, oxidative stress related disorders such as Parkinson's and stroke, neurological disorders, ophthalamic disorders, cardiovascular disease, and obesity.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: July 14, 2015
    Assignee: GTX, INC.
    Inventors: James T. Dalton, Duane D. Miller, Michael L. Mohler, Seoung-Soo Hong, Zhongzhi Wu, Devesh Srivastava
  • LPAreceptor-specific benzoic acid derivatives
    Patent number: 9056835
    Abstract: Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: June 16, 2015
    Assignee: The University of Tennessee Research Foundation
    Inventors: Renukadevi Patil, James Fells, Duane D. Miller, Gabor Tigyi
  • Compounds for treatment of cancer
    Patent number: 9029408
    Abstract: The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: May 12, 2015
    Assignees: GTx, Inc., University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Wei Li, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn
  • Selective androgen receptor modulators for treating diabetes
    Patent number: 8853266
    Abstract: This invention provides use of a SARM compound or a composition comprising the same in treating a variety of diseases or conditions in a subject, including, inter-alia, a diabetes disease, and/or disorder such as cardiovascular disease, atherosclerosis, cerebrovascular conditions, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: October 7, 2014
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller
  • COMPOUNDS WITH INCREASED SPECIFICITY FOR THE TREATMENT OF GLIOMA
    Publication number: 20140296286
    Abstract: Disclosed are compounds for the treatment of cancer. Compounds disclosed herein are particularly effective for the selective inhibition of glioma cells.
    Type: Application
    Filed: March 25, 2014
    Publication date: October 2, 2014
    Applicant: University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Shivaputra Appanna Patil, Renukadevi Patil, Terreia Jones, Amira Ahmed, Likeselam Asres, Charles Ryan Yates, Eldon Geisert
  • Substituted acylanilides and methods of use thereof
    Patent number: 8846756
    Abstract: This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: September 30, 2014
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller
  • Compounds for treatment of cancer
    Patent number: 8822513
    Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: September 2, 2014
    Assignees: GTX, Inc., University of Tennessee Research Foundation
    Inventors: Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. Dalton, Duane D. Miller, Charles Duke, Sunjoo Ahn
  • Regenerable MgO promoted metal oxide oxygen carriers for chemical looping combustion
    Patent number: 8807988
    Abstract: The disclosure provides an oxygen carrier comprised of a plurality of metal oxide particles in contact with a plurality of MgO promoter particles. The MgO promoter particles increase the reaction rate and oxygen utilization of the metal oxide when contacting with a gaseous hydrocarbon at a temperature greater than about 725° C. The promoted oxide solid is generally comprised of less than about 25 wt. % MgO, and may be prepared by physical mixing, incipient wetness impregnation, or other methods known in the art. The oxygen carrier exhibits a crystalline structure of the metal oxide and a crystalline structure of MgO under XRD crystallography, and retains these crystalline structures over subsequent redox cycles. In an embodiment, the metal oxide is Fe2O3, and the gaseous hydrocarbon is comprised of methane.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: August 19, 2014
    Assignee: U.S. Department Of Energy
    Inventors: Ranjani V. Siriwardane, Duane D. Miller
  • SARMS AND METHOD OF USE THEREOF
    Publication number: 20140221479
    Abstract: This invention is directed to a feed composition and method of affecting the carcass composition by increasing the lean mass, reducing the fat mass, and/or reducing the percent fat mass comprising SARM compounds.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 7, 2014
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: James T. Dalton, Duane D. Miller, Jeffrey D. Kearbey
  • COMPOUNDS FOR TREATMENT OF CANCER
    Publication number: 20140213623
    Abstract: The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
    Type: Application
    Filed: October 9, 2013
    Publication date: July 31, 2014
    Applicants: GTx, Inc., University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Li Wei, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn