Patents by Inventor Duane E. Day

Duane E. Day has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies
    Patent number: 9085795
    Abstract: The present invention relates to antibodies that bind to prorenin. In particular, the invention relates to monoclonal antibodies that bind to prorenin and inhibit the activation of prorenin. The antibodies of the invention are useful for screening for candidate agents that inhibit the activation of prorenin and candidate agents the modulate the activity of renin. The antibodies are also useful as diagnostics and for treating disease states.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: July 21, 2015
    Assignee: MOLECULAR INNOVATIONS, INC.
    Inventor: Duane E. Day
  • Methods For Screening Candidate Agents For Modulating Prorenin And Renin, Assays for Detecting Prorenin And Antibodies
    Publication number: 20100196367
    Abstract: The present invention relates to antibodies that bind to prorenin. In particular, the invention relates to monoclonal antibodies that bind to prorenin and inhibit the activation of prorenin. The antibodies of the invention are useful for screening for candidate agents that inhibit the activation of prorenin and candidate agents the modulate the activity of renin. The antibodies are also useful as diagnostics and for treating disease states.
    Type: Application
    Filed: February 4, 2010
    Publication date: August 5, 2010
    Applicant: MOLECULAR INNOVATIONS
    Inventor: Duane E. Day
  • Novel Protein Fusion/Tag Technology
    Publication number: 20090169553
    Abstract: The present invention relates to fusion molecules comprising at least one first purification domain and a molecule of interest, wherein the purification domain is selected from the group consisting of a kringle domain and a staphylocoagulase D2 domain. The present invention further relates to methods of purifying a molecule of interest using the fusion molecules of the invention. Also provided is a method of making an antibody using the fusion molecules of the invention, wherein the purification domain is a kringle domain. In addition, the present invention provides for vaccines which have reduced immunoreactivity and which comprise a fusion molecule having a kringle domain and an immunogenic domain.
    Type: Application
    Filed: May 3, 2007
    Publication date: July 2, 2009
    Inventor: Duane E. Day
  • Active site labelling of plasminogen
    Patent number: 5187069
    Abstract: A plasminogen, which has a label incorporated into an active site thereof such that said plasminogen is enzymatically and catalytically inactive upon its conversion to plasmin, and an enzymatically and catalytically inactive plasmin with a label incorporated into an active site thereof.A method of making a labelled plasminogen which is enzymatically and catalytically inactive upon conversion to plasmin is provided along with an assay method which utilizes a labelled plasminogen.
    Type: Grant
    Filed: August 6, 1990
    Date of Patent: February 16, 1993
    Assignee: Henry Ford Health System
    Inventors: Joseph D. Shore, Paul E. Bock, Steven T. Olson, Duane E. Day