Patents by Inventor Duane E. Rudisill

Duane E. Rudisill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel intermediates useful for the preparation of antihistaminic piperidine derivatives
    Publication number: 20010000038
    Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula 1
    Type: Application
    Filed: December 1, 2000
    Publication date: March 15, 2001
    Inventors: Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
  • Intermediates useful for the preparation of antihistaminic piperidine derivatives
    Patent number: 6147216
    Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hydrogen;R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;n is an integer of from 1 to 5;m is an integer 0 or 1;R.sub.3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R.sub.1 and R.sub.2 are ta to form a second bond between the carbon R.sub.1 and R.sub.2 or where R.sub.1 represented hydroxy integer 0.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 14, 2000
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Richard C. Krauss, Robert M. Strom, Carey L. Scortichini, William J. Kruper, Richard A. Wolf, Weishi W. Wu, Albert A. Carr, David A. Hay, Duane E. Rudisill, Gianbattista Panzone
  • Process for the preparation of N-methyl-D-phenylalanyl-N-?1-?3-?(aminoiminomethyl)amino!propyl!-3,3-dif luoro-2-oxohexyl!-L-prolinamide
    Patent number: 5739354
    Abstract: The present invention relates to a novel process for preparing preparing N-methyl-D-phenylalanyl-N-?1-?3-?(aminoiminomethyl)amino!propyl!-3,3-diflu oro-2-oxohexyl!-L-prolinamide or a pharmaceutically acceptable salt thereof and to a key intermediate by directly guanylating Dakin-West intermediates.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: April 14, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventor: Duane E. Rudisill
  • N-trityl protected aspartic acid derivatives for the preparation of phosphonate NMDA antagonists
    Patent number: 5554773
    Abstract: The present invention related to novel (R)-dimethyl N-tritylaspartate and novel (R)-alkyl N-trityl-4-oxo-5-phosphononorvalinate derivatives which are useful in the preparation of the class of beta-ketophosphonate NMDA antagonists.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: September 10, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Jeffrey P. Whitten, Duane E. Rudisill