Abstract: A process for increasing the percentage of active ingredient relative to non-active excipient in a compressible formulation, and also for reducing tablet size, by excluding an amount of the excipient and including in its place a reduced amount of a polysaccharide material.

Abstract: A method is described for the direct compression of particles comprising the steps of subjecting a suspension comprising particles of an active material and a compression excipient in a fluid medium to a pressure force to form a suspension of modified particles, removing said modified particles from said fluid medium to form a dried homogenate; and directly compressing said dried homogenate. The method prepares high active-loaded compression forms by direct compressing a mixture of active material with an excipient composition containing a non-ionic hydrophilic polymer, and a polysaccharide. Also described is a direct compression excipient composition comprising polysaccharide and a non-ionic hydrophilic polymer, which excipient may be combined with an aqueous suspension of the difficult-to-compress active, dried and compressed into a form acceptable for purposes including pharmaceutical applications.