Patents by Inventor Duane S. JUANG
Duane S. JUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117452Abstract: Provided herein are systems and methods for isolating a target from a biological sample. In some aspects, provided herein are automated systems and methods for isolating a target from a plurality of biological samples. For example, provided herein are automated systems and methods for isolating viral nucleic acid from a biological sample using a magnetic force to draw the nucleic acid out of a liquid biological sample.Type: ApplicationFiled: January 5, 2022Publication date: April 11, 2024Inventors: Jay Warrick, Brianna Mullins, Patrick McMinn, Dave Beebe, Ryan Shogren, Mitch Geiger, Franklin Zhong, Duane S. Juang, Terry D. Juang
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Publication number: 20240061002Abstract: Provided herein are mobile systems for sample processing. In some aspects, provided herein are mobile systems for sample processing and methods of use thereof for detection of pathogens in biological samples.Type: ApplicationFiled: January 5, 2022Publication date: February 22, 2024Inventors: Peter James Dailey, Richard McGregor Thayer, Laura Terese Mazzola, Paul Scott Eastman, Michael S. Urdea, Jesse Charles Darley, Ryan Lee Anton, Katherine Gail Mason, Sara Willoughby Berg-Love, Justin Daniel Chan, Russell Prince, Douglas Paul Barnes, Evan Alex Bunke, Jacob Emory Schepp, Douglas E. Seals, Alexandra A. Surasky-Ysasi, Angie Purvis, Christina Newman, Dawn Dudley, David O'Connor, Thomas Friedrich, Steven Carbone, Madalyn Gill, Brianna Mullins, Jay Warrick, Patrick McMinn, Dave Beebe, Ryan Shogren, Mitch Geiger, Franklin Zhong, Duane S. Juang, Terry D. Juang
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Patent number: 11717830Abstract: An open microfluidic system is provided. The open microfluidic system including the extreme wettability of exclusive liquid repellency (ELR), open microchannels with high lateral resolution and low profile, various valve arrangements, capable of a broad range flow rates, and capable of spatially and temporally trapping particles in open fluid.Type: GrantFiled: June 26, 2020Date of Patent: August 8, 2023Assignee: Wisconsin Alumni Research FoundationInventors: Chao Li, David J. Beebe, Duane S. Juang
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Patent number: 11691145Abstract: A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.Type: GrantFiled: October 7, 2021Date of Patent: July 4, 2023Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Duane S. Juang, Jiaquan Yu, Jo Handelsman
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Patent number: 11618021Abstract: A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to repel an aqueous solution. A dried reagent is provided on a portion of the surface and the reservoir is filled with an oil. A first droplet formed from the aqueous solution is positioned on the dried reagent so to pick-up and re-dissolve the dried reagent therein so as to expose the portion of the surface. In addition, a second droplet of an aqueous solution may be deposited on a hydrophilic spot patterned on the surface. A magnetic force may be configured to interact magnetically with the paramagnetic beads within the first droplet to move the droplet through the oil in the reservoir or to move the paramagnetic beads from the first droplet, through the oil, into the second droplet.Type: GrantFiled: June 26, 2020Date of Patent: April 4, 2023Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Joshua M. Lang, Duane S. Juang, Scott M. Berry, Tamara S. Rodems
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Patent number: 11384326Abstract: A target particle transferring device is disclosed, which comprises: (a) a substrate with a thickness of T and a width of W, having top and bottom portions, the top portion having a top surface and the bottom portion having a bottom surface; (b) a notch structure formed in the bottom portion of the substrate, comprising: a groove with a width of W1, located at a distance oft below the top surface of the substrate, wherein the groove is formed in the bottom portion from the bottom surface extending toward the top portion; and (c) a target substrate portion with a width of W2 and a thickness of T, located in the top and bottom portions of the substrate and being surrounded by the groove. Methods of transferring a target particle from one device to another is also disclosed.Type: GrantFiled: November 18, 2016Date of Patent: July 12, 2022Assignee: NATIONAL HEALTH RESEARCH INSTITUTESInventors: Chia-Hsien S. Hsu, Ching-Hui Lin, Duane S. Juang, Hao-Chen Chang
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Publication number: 20220097058Abstract: A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.Type: ApplicationFiled: October 7, 2021Publication date: March 31, 2022Inventors: David J. Beebe, Duane S. Juang, Jiaquan Yu, Jo Handelsman
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Publication number: 20210379587Abstract: A method and device are provided for detecting a target in a biological sample. The target binds to a solid phase substrate. First and second cavities in a plate are filled with an oil. The first and second cavities are in fluid communication with each other. The solid phase substrate is magnetically drawn sequentially from a drop of the biological sample in the first cavity, through the oil, into a drop of the reaction solution in the second cavity. A change in a parameter of the drop of the reaction solution indicates the presence of the target.Type: ApplicationFiled: June 5, 2020Publication date: December 9, 2021Inventors: David J. Beebe, Duane S. Juang, Terry D. Juang, Thomas C. Friedrich, David H. O'Connor
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Patent number: 11185860Abstract: A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.Type: GrantFiled: December 12, 2018Date of Patent: November 30, 2021Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Duane S. Juang, Jiaquan Yu, Jo Handelsman
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Publication number: 20210101149Abstract: An open microfluidic system is provided. The open microfluidic system including the extreme wettability of exclusive liquid repellency (ELR), open microchannels with high lateral resolution and low profile, various valve arrangements, capable of a broad range flow rates, and capable of spatially and temporally trapping particles in open fluid.Type: ApplicationFiled: June 26, 2020Publication date: April 8, 2021Inventors: Chao Li, David J. Beebe, Duane S. Juang
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Publication number: 20200406260Abstract: A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to repel an aqueous solution. A dried reagent is provided on a portion of the surface and the reservoir is filled with an oil. A first droplet formed from the aqueous solution is positioned on the dried reagent so to pick-up and re-dissolve the dried reagent therein so as to expose the portion of the surface. In addition, a second droplet of an aqueous solution may be deposited on a hydrophilic spot patterned on the surface. A magnetic force may be configured to interact magnetically with the paramagnetic beads within the first droplet to move the droplet through the oil in the reservoir or to move the paramagnetic beads from the first droplet, through the oil, into the second droplet.Type: ApplicationFiled: June 26, 2020Publication date: December 31, 2020Inventors: David J. Beebe, Joshua M. Lang, Duane S. Juang, Scott M. Berry, Tamara S. Rodems
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Publication number: 20200188913Abstract: A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.Type: ApplicationFiled: December 12, 2018Publication date: June 18, 2020Inventors: David J. Beebe, Duane S. Juang, jiaquan Yu, Jo Handelsman
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Publication number: 20180334647Abstract: A target particle transferring device is disclosed, which comprises: (a) a substrate with a thickness of T and a width of W, having top and bottom portions, the top portion having a top surface and the bottom portion having a bottom surface; (b) a notch structure formed in the bottom portion of the substrate, comprising: a groove with a width of W1, located at a distance oft below the top surface of the substrate, wherein the groove is formed in the bottom portion from the bottom surface extending toward the top portion; and (c) a target substrate portion with a width of W2 and a thickness of T, located in the top and bottom portions of the substrate and being surrounded by the groove. Methods of transferring a target particle from one device to another is also disclosed.Type: ApplicationFiled: November 18, 2016Publication date: November 22, 2018Inventors: Chia-Hsien S. Hsu, Ching-Hui Lin, Duane S. Juang, Hao-Chen Chang
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Publication number: 20170145363Abstract: A microfluidic dual-well device is disclosed. The device comprises: (a) a first substrate having a first end, a second end, and a culture microwell forming portion; (b) a plurality of culture microwells; (c) a second substrate having a first end, a second end, and a capture microwell forming portion, the two ends of the second substrate being respectively bounded to the two ends of the first substrate; (d) a plurality of capture microwells; (e) a microfluidic channel; (f) a microfluidic inlet port; and (g) a microfluidic outlet port; wherein the microfluidic channel is in fluidic connections with the culture microwells, the capture microwells, and the inlet and outlet ports. Methods of capturing and transferring a single cell or a single cell colony for culture, and method of transferring a target cell from a polydimethylsiloxane (PDMS) structure of culture microwells to a culture plate for culture are also disclosed.Type: ApplicationFiled: May 19, 2016Publication date: May 25, 2017Inventors: Chia-Hsien HSU, Ching-Hui LIN, Duane S. JUANG, Hao-Chen CHANG, Ing-Ming CHIU