Patents by Inventor Duane T. Gish

Duane T. Gish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arabinofuranosyl N.sup.4 -aminoacyl cytosine containing compounds
    Patent number: 3975367
    Abstract: Certain new 1-(3',5'-O-Variable-.beta.-D-arabinofuranosyl)-N.sup.4 -.alpha.-aminoacylcytosines, for example, 1-(5'-O-palmitoyl-.beta.-D-arabinofuranosyl)-N.sup.4 -[N.sup..alpha.-[N-(tert-butoxycarbonyl)glycyl]-L-arginyl]cytosine hydrochloride, have been found active against neoplastic cells, viruses, and as immunosuppressants. The 3'-O-, or 5'-O-, variability includes the hydrogen atom and acyl groups. The N.sup.4 -.alpha.-aminoacyl group comprises .alpha.-amino acids, N-protected .alpha.-amino acids, and similar peptidyl sequences of .alpha.-amino acids. Acid addition salts are an embodiment of the invention.
    Type: Grant
    Filed: August 30, 1974
    Date of Patent: August 17, 1976
    Assignee: The Upjohn Company
    Inventors: Duane T. Gish, Gary D. Gray, William J. Wechter