Patents by Inventor Dudley E. McMackins

Dudley E. McMackins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5624956
    Abstract: Novel urea derivatives and pharmaceutical compositions thereof are provided which inhibit platelet aggregation.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 29, 1997
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5475025
    Abstract: Novel urea compounds are provided which inhibit platelet aggregation as well as pharmaceutical compositions and methods of using said compounds.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: December 12, 1995
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5314902
    Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: May 24, 1994
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5220050
    Abstract: This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 15, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Dudley E. McMackins, Joseph G. Rico, Foe S. Tjoeng, Mihaly V. Toth, Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki
  • Sorbic acid process
    Patent number: 4736063
    Abstract: Butadiene and acetic acid are reacted with metal ion oxidant to prepare acetoxyhexenoic acids which are then converted to sorbic acid.
    Type: Grant
    Filed: January 2, 1981
    Date of Patent: April 5, 1988
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Dudley E. McMackins
  • Acyloxyalkenoic acids and process therefor
    Patent number: 4672140
    Abstract: This disclosure concerns acyloxyhexenoic acids and their salts with the acids being produced by reaction of butadiene and acetic acid with metal salt oxidants in a process involving electrolytic regeneration of the metal oxidants during the reaction. Iosmeric acetoxyhexenoic acids produced can be readily converted to sorbic acid, and antimicrobial and preservative uses for the acids are also disclosed.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: June 9, 1987
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Dudley E. McMackins
  • Product separation from electrolyte salts maintained in molten state
    Patent number: 4564689
    Abstract: In processes for reacting acetic acid with butadiene in solvent to prepare acetoxyhexenoic acid and .gamma.-vinyl-.gamma.-butyrolactone, involving electrolytic regeneration of a metal ion oxidant such as trivalent manganese, the product separation is facilitated by using low melting electrolyte salts and separating product from salts maintained in a molten state.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: January 14, 1986
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Dudley E. McMackins
  • Production of lactone in molten salt electrolysis
    Patent number: 4560775
    Abstract: Butadiene and acetic acid are reacted with a metal salt oxidant in molten salt medium to form .gamma.-vinyl-.gamma.-butyrolactone. The process includes electrolytic regeneration of the oxidant and provides a simple reaction system which permits product recovery and reactant recycle without extensive solvent handling. A high surface area reactor can be employed.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 24, 1985
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Dudley E. McMackins, Charles R. Penquite, Steven R. Auvil
  • Synthesis of .gamma.-vinyl-.gamma.-butyrolactone from acetoxyhexenoic acids
    Patent number: 4526990
    Abstract: In the process of preparing acetoxyhexenoic acids from butadiene, acetic acid and acetic anhydride, selectivity is improved by converting the acetoxyhexenoic acids to .gamma.-vinyl-.gamma.-butyrolactone before isolation. Copper and platinum are useful catalysts in the conversion.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: July 2, 1985
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Thomas E. Rogers, Dudley E. McMackins
  • Lactone process
    Patent number: 4380650
    Abstract: Acyloxyhexenoic acids are converted to .gamma.-vinyl-.gamma.-butyrolactone.
    Type: Grant
    Filed: January 2, 1981
    Date of Patent: April 19, 1983
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Dudley E. McMackins
  • Acyloxyalkenoic acids and process therefor
    Patent number: 4356317
    Abstract: Acyloxyhexenoic acids are produced by reaction of butadiene and acetic acid with metal salt oxidants in a process involving electrolytic regeneration of the metal oxidants during the reaction.
    Type: Grant
    Filed: January 2, 1981
    Date of Patent: October 26, 1982
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Dudley E. McMackins
  • Asymmetric amination of 1,3-dienes
    Patent number: 4204997
    Abstract: A process for the asymmetric synthesis of amines which comprises the amination of a conjugated diene having from 4 to about 20 carbon atoms in the presence of a catalyst system comprising a palladium compound and an optically active phosphine ligand containing at least two phosphorus atoms.
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: May 27, 1980
    Assignee: Monsanto Company
    Inventors: Charles F. Hobbs, Dudley E. McMackins
  • Production of unsaturated amines
    Patent number: 4130590
    Abstract: N-(alkadienyl)amines are produced at a rapid rate and in high yield by the reaction of conjugated dienes with ammonia and amines in a hydroxylic solvent using a catalyst system comprising a palladium compound co-catalyzed with a phosphonite ligand.
    Type: Grant
    Filed: June 21, 1976
    Date of Patent: December 19, 1978
    Assignee: Monsanto Company
    Inventors: Charles F. Hobbs, Dudley E. McMackins
  • Production of primary and secondary amines by reaction of ammonia with conjugated diene in the presence of Pd/phosphine catalyst and primary or secondary aliphatic alcohol solvent medium
    Patent number: 4120901
    Abstract: Short chain, unsaturated primary and secondary amines are prepared by reaction of ammonia and conjugated dienes in a primary or secondary aliphatic alcohol solvent medium and in the presence of a catalyst system comprising a palladium compound co-catalyzed with a phosphine ligand containing 2 to 4 phosphorus atoms.
    Type: Grant
    Filed: August 31, 1977
    Date of Patent: October 17, 1978
    Assignee: Monsanto Company
    Inventors: Charles F. Hobbs, Dudley E. McMackins
  • Production of unsaturated amines employing a palladium compound co-catalyzed with a phosphonite ligand
    Patent number: 4100194
    Abstract: N-(alkadienyl)amines are produced at a rapid rate and in high yield by the reaction of conjugated dienes with ammonia and amines in a hydroxylic solvent using a catalyst system comprising a palladium compound co-catalyzed with a phosphonite ligand.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: July 11, 1978
    Assignee: Monsanto Company
    Inventors: Charles F. Hobbs, Dudley E. McMackins
  • Production of N-(alkadienyl)amines
    Patent number: 4100196
    Abstract: In the process of producing N-(alkadienyl)amines by the amination of conjugated dienes in a hydroxylic solvent medium in the presence of a catalyst comprising a palladium compound co-catalyzed with a phosphonite ligand, the improvement in which the phosphonite ligand is polymerized with polyvinyl alcohol whereby the catalyst can be readily separated from the liquid rection products.
    Type: Grant
    Filed: December 23, 1976
    Date of Patent: July 11, 1978
    Assignee: Monsanto Company
    Inventors: Charles F. Hobbs, Dudley E. McMackins