Patents by Inventor Dudley K. Strickland

Dudley K. Strickland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE
    Publication number: 20220332813
    Abstract: The present invention provides methods and compositions for reducing internalization and/or trafficking of tau in neuronal cells comprising contacting the cells with an effective amount of an LRP1 and/or SorLA antagonist. The invention further provides a method of treating or preventing Alzheimer's disease in a subject in need thereof, comprising administering to the subject an effective amount of an LRP1 and/or SorLA antagonist.
    Type: Application
    Filed: April 3, 2022
    Publication date: October 20, 2022
    Inventors: Dudley K. Strickland, Joanna Cooper, Selen M. Catania, Mary M. Migliorini, Brian Hampton, Bradley T. Hyman, Aurelien Lathuiliere
  • Modulators of expression and function of LRP in Alzheimer's disease
    Patent number: 6447775
    Abstract: The present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid &bgr;-precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or binding of APP with members of the low density lipoprotein receptor family.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: September 10, 2002
    Assignees: The General Hospital Corporation, American National Red Cross
    Inventors: Dudley K. Strickland, Bradley T. Hyman, Maria Z. Kounnas, Robert D. Moir, Rudolph E. Tanzi, G. William Rebeck
  • Modulators of expression and function of LRP in alzheimer's disease
    Patent number: 6156311
    Abstract: The present invention broadly relates to the treatment, diagnosis, and prophylactic prevention of Alzheimer's disease. More specifically, the present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid .beta.-precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or binding of APP with members of the low density lipoprotein receptor family.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: December 5, 2000
    Assignees: The American National Red Cross, The General Hospital Corporation
    Inventors: Dudley K. Strickland, Bradley T. Hyman, Maria Z. Kounnas, Robert D. Moir, Rudolph E. Tanzi