Patents by Inventor Dudley S. Jayasinghe

Dudley S. Jayasinghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Treatment with Drug Eluting Stents with Prolonged Local Elution Profiles with High Local Concentrations and Low Systemic Concentrations
    Publication number: 20160250049
    Abstract: A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ?g/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
    Type: Application
    Filed: May 13, 2016
    Publication date: September 1, 2016
    Inventors: Kent C.B. STALKER, Winnette S. MCINTOSH, Dudley S. JAYASINGHE, Gregory C. ORR, John E. PAPP, Lewis B. SCHWARTZ
  • Methods of treatment with drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations
    Patent number: 9358096
    Abstract: A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ?g/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: June 7, 2016
    Assignee: Abbott Laboratories
    Inventors: Kent C. B. Stalker, Winnette S. McIntosh, Dudley S. Jayasinghe, Gregory C. Orr, John E. Papp, Lewis B. Schwartz
  • BIORESORBABLE POLYMER PERIPHERAL SCAFFOLDS MADE FROM BLOCK COPOLYMERS OF POLY(L-LACTIDE) AND HYDROPHILIC POLYMERS
    Publication number: 20130338762
    Abstract: Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed The scaffolds are made from a block copolymer of PLLA and a hydrophilic polymer.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 19, 2013
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Dudley S. Jayasinghe, Dariush Davalian, Ronald A. Farnbach
  • Methods Of Treatment With Drug Eluting Stents With Prolonged Local Elution Profiles With High Local Concentrations And Low Systemic Concentrations
    Publication number: 20130268061
    Abstract: A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ?g/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 10, 2013
    Inventors: Kent C.B. Stalker, Winnette S. McIntosh, Dudley S. Jayasinghe, Gregory C. Orr, John E. Papp, Lewis B. Schwartz
  • DRUG ELUTING STENTS WITH PROLONGED LOCAL ELUTION PROFILES WITH HIGH LOCAL CONCENTRATIONS AND LOW SYSTEMIC CONCENTRATIONS
    Publication number: 20090093875
    Abstract: A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 ug/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.
    Type: Application
    Filed: April 30, 2008
    Publication date: April 9, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Kent C. B. Stalker, Winnette S. McIntosh, Dudley S. Jayasinghe, Gregory C. Orr, John E. Papp, Lewis B. Schwartz