Abstract: In one aspect, amphiphilic block copolymers are described herein comprising a first block and a second block, the second block including monomer having a side chain comprising a heteroaryl moiety, wherein the second block is more hydrophobic than the first block. In some embodiments, the heteroaryl moiety is a five-membered ring or six membered ring. Amphiphilic block copolymers described herein, in some embodiments, can be used to form micellar compositions for solubilizing and delivering water insoluble pharmaceutical and/or therapeutic agents.