Patents by Inventor Dumitru Constantin-Teodosiu

Dumitru Constantin-Teodosiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carnitine retention
    Patent number: 9662344
    Abstract: A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or increase blood/plasma insulin concentration.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: May 30, 2017
    Assignees: The University of Nottingham, Lonza Sales LTD.
    Inventors: Paul Leonard Greenhaff, Dumitru Constantin-Teodosiu
  • Carnitine Retention
    Publication number: 20140378397
    Abstract: A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or to increase blood/plasma insulin concentration.
    Type: Application
    Filed: July 28, 2014
    Publication date: December 25, 2014
    Inventors: Paul Leonard Greenhaff, Dumitru Constantin-Teodosiu
  • REGULATING FAT AND CARBOHYDRATE OXIDATION IN MUSCLE TISSUE COMPRISING CONTROLLING GARNITINE CONTENT IN MUSCLE
    Publication number: 20090312237
    Abstract: Methods, compositions and substances for regulating fat and carbohydrate oxidation in the muscle tissue of human and/or animal bodies, which involve controlling the carnitine content of the muscle tissue. Regulating carbohydrate and fat oxidation, and particularly increasing the level of fat oxidation in accordance with the present invention, by providing substances compositions and methodologies in accordance with the present invention, enable medicaments to be manufactured and methodologies employed that find use in the treatment of disorders and conditions of the human and/or animal body caused by impairment of the usual level of fat oxidation, including obesity and type 2 diabetes.
    Type: Application
    Filed: April 2, 2007
    Publication date: December 17, 2009
    Applicant: THE UNIVERSITY OF NOTTINGHAM
    Inventors: Paul Leonard Greenhaff, Dumitru Constantin-Teodosiu
  • Carnitine retention
    Publication number: 20060240075
    Abstract: A composition for influencing carnitine retention in biological tissue is disclosed. The composition comprises a carnitine substance and an agent to increase sodium potassium ATPase pump activity in the tissue, and/or to increase the activity of a carnitine transport protein, and/or increase blood/plasma insulin concentration.
    Type: Application
    Filed: March 22, 2004
    Publication date: October 26, 2006
    Inventor: Dumitru Constantin-Teodosiu
  • Use for a pyruvate dehydrogenase activator for the treatment of ischaemia in limbs
    Publication number: 20030013764
    Abstract: Agents which inhibit PDH kinase such as dichloroacetic acid, its salts and derivatives are described as being useful in the treatment of ischaemia in limbs. In particular, dichloroacetic acid and its salts are useful in treating intermittent claudification.
    Type: Application
    Filed: December 21, 2001
    Publication date: January 16, 2003
    Inventors: Dumitru Constantin-Teodosiu, James Archibald Timmons, Paul Leonard Greenhaff, Simon Martin Poucher
  • Reducing muscle fatigue
    Patent number: 6143784
    Abstract: A method of reducing muscle fatigue during exercise or for treating chronic heart failure, the method comprising increasing the concentration of TCA cycle intermediates in the muscle mitochondria by the administration of pyruvate to the body.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: November 7, 2000
    Assignee: The University of Nottingham
    Inventors: Paul Leonard Greenhaff, Elizabeth Jane Simpson, Dumitru Constantin-Teodosiu