Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for unmasking a masked representation of a protein using a protein reconstruction neural network. In one aspect, a method comprises: receiving the masked representation of the protein; and processing the masked representation of the protein using the protein reconstruction neural network to generate a respective predicted embedding corresponding to one or more masked embeddings that are included in the masked representation of the protein, wherein a predicted embedding corresponding to a masked embedding in a representation of the amino acid sequence of the protein defines a prediction for an identity of an amino acid at a corresponding position in the amino acid sequence, wherein a predicted embedding corresponding to a masked embedding in a representation of the structure of the protein defines a prediction for a corresponding structural feature of the protein.

Abstract: In certain embodiments, a (CBSD) base station for a (CBRS) radio system transmits new information elements in an existing capability exchange message to a spectrum access system (SAS) informing the SAS as to whether the SAS should transmit a channel-change message to the base station either (i) directly (and despite of domain proxy being present in the communication path) or (ii) via a domain proxy. If and when the SAS subsequently receives notification of incumbent activity from an Environmental Sensing Capability system, the SAS transmits either a new channel-change message or includes new information elements in an existing heartbeat message to the base station either (i) directly or (ii) via the domain proxy per the capability exchange message.

Abstract: In certain embodiments, a (CBSD) base station for a (CBRS) radio system transmits new information elements in an existing capability exchange message to a spectrum access system (SAS) informing the SAS as to whether the SAS should transmit a channel-change message to the base station either (i) directly (and despite of domain proxy being present in the communication path) or (ii) via a domain proxy. If and when the SAS subsequently receives notification of incumbent activity from an Environmental Sensing Capability system, the SAS transmits either a new channel-change message or includes new information elements in an existing heartbeat message to the base station either (i) directly or (ii) via the domain proxy per the capability exchange message.

Abstract: A reinforcement learning neural network system in which internal representations and policies are grounded in visual entities derived from image pixels comprises a visual entity identifying neural network subsystem configured to process image data to determine a set of spatial maps representing respective discrete visual entities. A reinforcement learning neural network subsystem processes data from the set of spatial maps and environmental reward data to provide action data for selecting actions to perform a task.

Abstract: A reinforcement learning neural network system in which internal representations and policies are grounded in visual entities derived from image pixels comprises a visual entity identifying neural network subsystem configured to process image data to determine a set of spatial maps representing respective discrete visual entities. A reinforcement learning neural network subsystem processes data from the set of spatial maps and environmental reward data to provide action data for selecting actions to perform a task.

Abstract: The present invention provides a process for producing the compound having the structure: comprising (a) reacting a compound having the structure: with a compound having the structure: in the presence of a first organic solvent under conditions sufficient to produce the compound, wherein the first organic solvent is a substituted benzene.

Abstract: The present invention provides a process for producing the compound having the structure: comprising (a) reacting a compound having the structure: with a compound having the structure: in the presence of a first organic solvent under conditions sufficient to produce the compound, wherein the first organic solvent is a substituted benzene.

Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.

Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.

Abstract: Provided herein are pharmaceutical compositions or dosage forms comprising crystalline 5-azacytidine monohydrate. The pharmaceutical compositions or dosage forms provided herein may be used for oral administration in the treatment of diseases, including the treatment of myelodysplastic syndromes (MDS).

Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.

Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.

Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.

Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.

Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.

Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.

Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.

Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.

Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.