Abstract: A method for integrated design of compressor blade and casing treatment is applied in the field of turbomachinery. The method includes: determining a parameterization method for blade and casing treatment based on a compressor blade model and a casing treatment model, respectively; obtaining an initial parameter set by using a sampling technology; and obtaining a design with a wide stability margin by using an advanced optimization algorithm without reducing a compressor efficiency. The method may couple an interaction between blades and casing treatment, greatly improving fitness of the casing treatment, so that the compressor may operate stably over a wide working range and R&D costs may be saved.

Abstract: Described herein are compounds that can arrest mitotic cells and their use in the treatment of disorders such as cancers.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: Disclosed are a data flow table for high-speed large-scale concurrent data flows, method and apparatus for processing the data flow table, and a storage medium. The method includes: acquiring, according to a data flow identifier of a data flow to be inserted, addresses of candidate buckets in a fingerprint table and a data flow fingerprint; detecting whether there is an idle unit in the candidate buckets in the fingerprint table, if there is an idle unit, selecting the candidate bucket having the idle unit as target bucket; and sequentially searching for the idle unit from bottom unit to top unit of the target bucket, and when the idle unit is found in the target bucket, writing data flow fingerprint of said data flow into the found idle unit, and writing data flow record of said data flow into a recording bucket corresponding to the candidate bucket.

Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula Ito a patient in need thereof.

Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.

Abstract: The disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.

Abstract: The present invention generally relates to inhibitor compounds and their use to selectively kill a class of cancer cells. Methods and means related to the treatment of cancers which overexpress the MYC family of oncogenes using Rho-associated protein kinase inhibitors, such as dimethylfasudil, which have shown to elicit cellular apoptosis, are provided herein.

Abstract: The present invention relates to methods of making RNAi libraries using E. coli RNAse III for inhibition of mammalian gene expression.

Abstract: The present invention relates to methods of making RNAi libraries using E. coli RNAse III for inhibition of mammalian gene expression.