Patents by Inventor Duncan Alexander HAY
Duncan Alexander HAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132467Abstract: Compounds of general formula (I): (I) wherein R1, R2, R3, R4, R5, Y and Z are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.Type: ApplicationFiled: June 9, 2023Publication date: April 25, 2024Applicant: TMEM16A LimitedInventors: Stephen COLLINGWOOD, Jonathan David Hargrave, Duncan Alexander Hay, Clive McCarthy, Thomas Beauregard Schofield, Edward Walker, Naomi Went
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Publication number: 20240067653Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.Type: ApplicationFiled: June 30, 2023Publication date: February 29, 2024Applicant: ENTERPRISE THERAPEUTICS LIMITEDInventors: Clive McCARTHY, Jonathan David HARGRAVE, Duncan Alexander HAY, Thomas Beauregard SCHOFIELD, Naomi WENT
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Patent number: 11739094Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.Type: GrantFiled: November 24, 2020Date of Patent: August 29, 2023Assignee: ENTERPRISE THERAPEUTICS LIMITEDInventors: Clive McCarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Naomi Went
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Publication number: 20220395512Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.Type: ApplicationFiled: May 17, 2022Publication date: December 15, 2022Inventors: Stephen Collingwood, Clive Mccarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Sarah Ellam, Craig Stephen Buxton, Matthew Habgood, Peter Neville Ingram, Chun Yan Ma, Spencer Charles Robert Napier, Abdul Kadar Shaikh, Matthew Raymond Smith, Christopher Charles Stimson, Edward Richard Walker
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Patent number: 11370778Abstract: The present invention discloses bis(pentahydroxyhexyl)amino substituted 2-{[(3-amino-pyrazin-2-yl)formamido]methyl}-1H-1,3-benzodiazol-3-ium derivatives of formula (I) as inhibitors of ENaC and are of use in the treatment of respiratory diseases and conditions, skin conditions or ocular conditions, wherein the respiratory disease or condition is e.g. cystic fibrosis, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiectasis, including non-cystic fibrosis bronchiectasis, and asthma; the skin condition is e.g. psoriasis, atopic dermatitis and ichthyosis; and the ocular condition is e.g. dry eye disease.Type: GrantFiled: October 17, 2018Date of Patent: June 28, 2022Assignee: Enterprise Therapeutics LimitedInventors: Duncan Alexander Hay, Thomas Beauregard Schofield, Naomi Went, Clive McCarthy
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Patent number: 11364246Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.Type: GrantFiled: November 22, 2019Date of Patent: June 21, 2022Assignee: TMEM16A LIMITEDInventors: Stephen Collingwood, Clive Mccarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Sarah Ellam, Craig Stephen Buxton, Matthew Habgood, Peter Neville Ingram, Chun Yan Ma, Spencer Charles Robert Napier, Abdul Kadar Shaikh, Matthew Raymond Smith, Christopher Charles Stimson, Edward Richard Walker
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Publication number: 20220098167Abstract: Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: wherein represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.Type: ApplicationFiled: December 10, 2021Publication date: March 31, 2022Inventors: Stephen COLLINGWOOD, Clive MCCARTHY, Duncan Alexander HAY, Jonathan David HARGRAVE, Albert MA, Thomas Beauregard SCHOFIELD, Matthew SMITH, Edward WALKER, Naomi WENT, Peter INGRAM, Christopher STIMSON, Someina KHOR
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Publication number: 20220098164Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, A, Z1, Z2 and Y are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.Type: ApplicationFiled: December 10, 2021Publication date: March 31, 2022Inventors: Stephen COLLINGWOOD, Jonathan David HARGRAVE, Duncan Alexander HAY, Edward WALKER
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Publication number: 20210188855Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.Type: ApplicationFiled: May 17, 2019Publication date: June 24, 2021Applicant: Enterprise Therapeutics LimitedInventors: Clive McCARTHY, Duncan Alexander HAY, Thomas Beauregard SCHOFIELD
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Publication number: 20210147432Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.Type: ApplicationFiled: November 24, 2020Publication date: May 20, 2021Applicant: ENTERPRISE THERAPEUTICS LIMITEDInventors: Clive McCARTHY, Jonathan David HARGRAVE, Duncan Alexander HAY, Thomas Beauregard SCHOFIELD, Naomi WENT
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Patent number: 10941149Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.Type: GrantFiled: November 22, 2017Date of Patent: March 9, 2021Assignee: Enterprise Therapeutics LimitedInventors: Clive McCarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Naomi Went
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Publication number: 20200383988Abstract: Compounds of general formula (1): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the N H calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.Type: ApplicationFiled: November 22, 2019Publication date: December 10, 2020Inventors: Stephen Collingwood, Clive Mccarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Sarah Ellam, Craig Buxton, Matthew Habgood, Peter Ingram, Chun Yan Ma, Spencer Napier, Abdul Shaikh, Matthew Smith, Christopher Stimson, Edward Walker
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Publication number: 20200361871Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.Type: ApplicationFiled: July 30, 2020Publication date: November 19, 2020Inventors: Stephen Collingwood, Clive Mccarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Sarah Ellam, Craig Buxton, Matthew Habgood, Peter Ingram, Chun Yan Ma, Spencer Napier, Abdul Shaikh, Matthew Smith, Christopher Stimson, Edward Walker
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Patent number: 10759785Abstract: The invention relates to compounds of general formula (I): wherein R1, R2, R3, R10 and X? are as defined herein. The compounds are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions.Type: GrantFiled: June 21, 2017Date of Patent: September 1, 2020Assignee: Enterprise Therapeutics LimitedInventors: Clive McCarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Naomi Went
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Publication number: 20200239442Abstract: The present invention discloses bis(pentahydroxyhexyl)amino substituted 2-{[(3-amino-pyrazin-2-yl)formamido]methyl}-1H-1,3-benzodiazol-3-ium derivatives of formula (I) as inhibitors of ENaC and are of use in the treatment of respiratory diseases and conditions, skin conditions or ocular conditions, wherein the respiratory disease or condition is e.g. cystic fibrosis, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiectasis, including non-cystic fibrosis bronchiectasis, and asthma; the skin condition is e.g. psoriasis, atopic dermatitis and ichthyosis; and the ocular condition is e.g. dry eye disease.Type: ApplicationFiled: October 17, 2018Publication date: July 30, 2020Applicant: ENTERPRISE THERAPEUTICS LIMITEDInventors: Duncan Alexander HAY, Thomas Beauregard SCHOFIELD, Naomi WENT, Clive McCARTHY
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Publication number: 20190315757Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.Type: ApplicationFiled: November 22, 2017Publication date: October 17, 2019Applicant: ENTERPRISE THERAPEUTICS LIMITEDInventors: Clive McCARTHY, Jonathan David HARGRAVE, Duncan Alexander HAY, Thomas Beauregard SCHOFIELD, Naomi WENT
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Publication number: 20190233402Abstract: The invention relates to compounds of general formula (I): wherein R1, R2, R3, R10 and X? are as defined herein. The compounds are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions.Type: ApplicationFiled: June 21, 2017Publication date: August 1, 2019Applicant: ENTERPRISE THERAPEUTICS LIMITEDInventors: Clive MCCARTHY, Jonathan David HARGRAVE, Duncan Alexander HAY, Thomas Beauregard SCHOFIELD, Naomi WENT