Patents by Inventor Duncan McGregor
Duncan McGregor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140154241Abstract: A modified igNAR peptide sequence derived from a wild-type igNAR peptide sequence is diversified by mutating the amino acid sequence at 50% or more of the amino acids in the CDR3 loop region and optionally at 50% or more of the amino acids in the CDR3 loop region. The modified igNAR peptide may have the sequence of SEQ ID NO: 8, 10 or 50 to 85. The modified igNAR peptides have binding activity against albumin protein sequences, such as human serum albumin. These modified igNAR peptides may have utility in extending the in vivo half-life of biological molecules e.g. therapeutic agents, and so may be used in medicine.Type: ApplicationFiled: December 5, 2011Publication date: June 5, 2014Applicant: CYCLOGENIX LTDInventors: Duncan McGregor, William Eldridge, Simon Robins, Marie Fernie, Tricia White, Stuart Pritchard, Susan King
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Patent number: 8735146Abstract: There is described a method of isolating nucleotide sequences encoding target peptides from DNA libraries using DNA binding proteins to link the peptide to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest, or from synthetic DNA, and inserted into, or adjacent to, a DNA binding protein in an expression vector to create a chimeric fusion protein. Incorporation of the vector DNA into a carrier package, during expression of the chimeric fusion protein, results in the production of a peptide display carrier package (PDCP) displaying the DNA-bound fusion protein on the external surface of the carrier package. Employment of affinity purification techniques results in the PDCP particles containing sequences encoding the desired peptide to be selected and the desired nucleotide sequences obtained therefrom.Type: GrantFiled: November 13, 2007Date of Patent: May 27, 2014Assignee: The University Court of the University of AberdeenInventor: Duncan McGregor
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Patent number: 8679781Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.Type: GrantFiled: October 21, 2010Date of Patent: March 25, 2014Assignee: Isogenica LimitedInventors: Duncan McGregor, Richard Odegrip, Kevin Fitzgerald, Rosemarie Hederer, Bill Eldridge, Chris Ullman, Philip Kuhlman, David Coomber
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Patent number: 8557744Abstract: A method is selects membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalized nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.Type: GrantFiled: July 24, 2006Date of Patent: October 15, 2013Assignee: Isogenica Ltd.Inventors: David Coomber, Kevin Fitzgerald, Duncan McGregor, Chris Ullman, Tomas Leanderson
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Patent number: 8267616Abstract: A pivot joint includes a first component (12) having a projecting boss form (16) and a second component (11) having an opening (25) for receiving the boss form (16). A headed fastener (32) and washer (27) engage with the boss form (16), which includes engagement elements (17) that dig into the washer (27) when the joint is assembled.Type: GrantFiled: July 11, 2007Date of Patent: September 18, 2012Assignee: Assa Abloy New Zealand LimitedInventor: Duncan McGregor
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Publication number: 20120149591Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.Type: ApplicationFiled: October 21, 2010Publication date: June 14, 2012Applicant: ISOGENICA LIMITEDInventors: Duncan MCGREGOR, Richard ODEGRIP, Kevin FIZGERALD, Rosemarie HEDERER, Bill ELDRIDGE, Chris ULLMAN, Philip KUHLMAN, David COOMBER
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Patent number: 7842476Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.Type: GrantFiled: September 5, 2003Date of Patent: November 30, 2010Assignee: Isogenica LimitedInventors: Duncan McGregor, Richard Odegrip, Kevin Fizgerald, Rosemarie Hederer, Bill Eldridge, Chris Ullman, Philip Kuhlman, David Coomber
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Publication number: 20100047009Abstract: A pivot joint includes a first component (12) having a projecting boss form (16) and a second component (11) having an opening (25) for receiving the boss form (16). A headed fastener (32) and washer (27) engage with the boss form (16), which includes engagement elements (17) that dig into the washer (27) when the joint is assembled.Type: ApplicationFiled: July 11, 2007Publication date: February 25, 2010Inventor: Duncan McGregor
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Publication number: 20080287311Abstract: A method is provided for selecting membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalised nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.Type: ApplicationFiled: July 24, 2006Publication date: November 20, 2008Applicant: Isogenica Ltd.Inventors: David Coomber, Kevin Fitzgerald, Duncan McGregor, Chris Ullman, Tomas Leanderson
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Publication number: 20080220981Abstract: There is described a method of isolating nucleotide sequences encoding target peptides from DNA libraries using DNA binding proteins to link the peptide to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest, or from synthetic DNA, and inserted into, or adjacent to, a DNA binding protein in an expression vector to create a chimeric fusion protein. Incorporation of the vector DNA into a carrier package, during expression of the chimeric fusion protein, results in the production of a peptide display carrier package (PDCP) displaying the DNA-bound fusion protein on the external surface of the carrier package. Employment of affinity purification techniques results in the PDCP particles containing sequences encoding the desired peptide to be selected and the desired nucleotide sequences obtained therefrom.Type: ApplicationFiled: November 13, 2007Publication date: September 11, 2008Applicant: Rowett Research InstituteInventor: Duncan McGregor
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Patent number: 7312074Abstract: There is described a method of isolating nucleotide sequences encoding target peptides from DNA libraries using DNA binding proteins to link the peptide to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest, or from synthetic DNA, and inserted into, or adjacent to, a DNA binding protein in an expression vector to create a chimeric fusion protein. Incorporation of the vector DNA into a carrier package, during expression of the chimeric fusion protein, results in the production of a peptide display carrier package (PDCP) displaying the DNA-bound fusion protein on the external surface of the carrier package. Employment of affinity purification techniques results in the PDCP particles containing sequences encoding the desired peptide to be selected and the desired nucleotide sequences obtained therefrom.Type: GrantFiled: September 2, 1998Date of Patent: December 25, 2007Inventor: Duncan McGregor
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Publication number: 20060035232Abstract: The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.Type: ApplicationFiled: September 5, 2003Publication date: February 16, 2006Inventors: Duncan McGregor, Richard Odegrip, Kevin Fizgerald, Rosemarie Hederer, Bill Eldridge, Chris Ullman, Philip Kuhlman, David Coomber
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Patent number: 6770616Abstract: A multi-phase detergent tablet for use in a washing machine, the tablet comprising a first phase in adhesive contact with one or more second phases, and wherein at least the first phase is in the form of a compressed particulate solid incorporating a cogranulated detergency additive composition comprising polymeric polycarboxylate and inorganic carrier. The multi-phase tablets provide improved interphase adhesivity, robustness and strength together with excellent dissolution and cleaning characteristics.Type: GrantFiled: September 4, 2001Date of Patent: August 3, 2004Assignee: The Procter & Gamble CompanyInventors: Steven Baldwin McGowan, James Iain Kinloch, Alasdair Duncan McGregor
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Patent number: 6451754Abstract: A process for preparing a detergent tablet comprises the steps of compressing a composition comprising an active detergent component to form a compressed portion and delivering a composition comprising an active detergent component in the form of a solid, liquid or gel to the compressed portion to form a non-compressed, non-encapsulating portion.Type: GrantFiled: February 2, 2000Date of Patent: September 17, 2002Assignee: The Procter & Gamble CompanyInventors: Barry Rowland, Alasdair Duncan McGregor, Michael Crombie Addison, Lynda Anne Speed
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Patent number: 6177393Abstract: A process for making a detergent composition comprising solid components which form a total particulate base detergent matrix and a liquid hydrocarbon component, the process comprises the steps of applying liquid hydrocarbon onto a high porosity fraction selected from the total particulate base detergent matrix.Type: GrantFiled: June 11, 1999Date of Patent: January 23, 2001Assignee: The Procter & Gamble CompanyInventors: Alasdair Duncan McGregor, Jane Margaret Warwick, Steven Baldwin McGowan
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Patent number: 6177398Abstract: A process for making a detergent tablet suitable for use in laundry or automatic dishwashing by tabletting a detergent composition comprising solid components which form a total particulate base detergent matrix and non-aqueous liquid components having viscosity of 1000 cp or less is disclosed. The process involves the steps of applying the non-aqueous liquid components having viscosity of 1000 cp or less onto a low porosity fraction selected from the total particulate base detergent matrix.Type: GrantFiled: June 10, 1999Date of Patent: January 23, 2001Assignee: The Procter & Gamble CompanyInventors: Alasdair Duncan McGregor, Jane Margaret Warwick
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Patent number: D420763Type: GrantFiled: May 26, 1998Date of Patent: February 15, 2000Assignee: The Procter & Gamble CompanyInventors: Jennifer Mary Forward, Alasdair Duncan McGregor, Rhona Alexandra Knox
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Patent number: D431094Type: GrantFiled: May 26, 1998Date of Patent: September 19, 2000Assignee: The Procter & Gamble CompanyInventors: Jennifer Mary Forward, Alasdair Duncan McGregor, Rhona Alexandra Knox