Patents by Inventor Duncan Roy Clark

Duncan Roy Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CREN7 CHIMERIC PROTEIN
    Publication number: 20110020877
    Abstract: There is provided a chimeric protein comprising a nucleic acid modifying enzyme domain having nucleic acid modifying activity joined with an Cren7 enhancer domain or variant thereof, in which the Cren7 enhancer domain or variant thereof enhances the activity of the nucleic acid modifying enzyme domain compared with a corresponding protein lacking the Cren7 enhancer domain or variant thereof. There is also provided an isolated nucleic acid encoding the chimeric protein of the invention and methods utilising the protein.
    Type: Application
    Filed: January 9, 2009
    Publication date: January 27, 2011
    Applicant: Genesys Limited
    Inventors: Duncan Roy Clark, Martin Wilkinson, Nicholas Morant
  • Kit for conducting a polymerase chain reaction
    Patent number: 7449312
    Abstract: A method for conducting a nucleic acid amplification reaction, said method comprising forming an amplification reaction mixture in the presence of sufficient of a pyrophosphate salt to prevent primer extension taking place, digesting said pyrophosphate salt with a pyrophosphatase enzyme (PPase), and subjecting said reaction mixture to conditions such that an amplification reaction may proceed. This can be used as a “hot start” amplification. Particular novel pyrophosphatase enzymes for use in the method are also described and claimed.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: November 11, 2008
    Assignee: The Secretary of State for Defense in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Duncan Roy Clark, Suzanne Patricia Vincent
  • Amplification process
    Patent number: 6951744
    Abstract: A method for conducting a nucleic acid amplification reaction, said method comprising forming an amplification reaction mixture in the presence of sufficient of a pyrophosphate salt to prevent primer extension taking place, digesting said pyrophosphate salt with a pyrophosphatase enzyme (PPase), and subjecting said reaction mixture to conditions such that an amplification reaction may proceed. This can be used as a “hot start” amplification. Particular novel pyrophosphatase enzymes for use in the method are also described and claimed.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: October 4, 2005
    Assignee: The Secretary of State for Defence
    Inventors: Duncan Roy Clark, Suzanne Patricia Vincent
  • Amplification process
    Publication number: 20030049655
    Abstract: A method for conducting a nucleic acid amplification reaction, said method comprising forming an amplification reaction mixture in the presence of sufficient of a pyrophosphate salt to prevent primer extension taking place, digesting said pyrophosphate salt with a pyrophosphatase enzyme (PPase), and subjecting said reaction mixture to conditions such that an amplification reaction may proceed.
    Type: Application
    Filed: April 30, 2002
    Publication date: March 13, 2003
    Inventors: Duncan Roy Clark, Suzanne Patricia Vincent