Publication number: 20150037348
Abstract: Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
Type:
Application
Filed:
July 10, 2014
Publication date:
February 5, 2015
Inventors:
Jochen G. Salfeld, Michael Roguska, Michael Paskind, Subhashis Banerjee, Daniel Edward Tracey, Michael White, Zehra Kaymakcalan, Boris Labkovsky, Paul Sakorafas, Geertruida M. Veldman, Amy Venturini, Angela Widom, Stuart Friedrich, Nicholas W. Warner, Angela Myles, John Gawain Elvin, Alexander Robert Duncan, Elaine Joy Derbyshire, Sara Carmen, Stephen Smith, Thor Las Holtet, Sarah Du Fou
Patent number: 8945779
Abstract: A main object of the present invention is to provide a solid electrolyte material having excellent Li ion conductivity. To attain the object, the present invention provides a solid electrolyte material represented by a general formula: Lix(La1-aM1a)y(Ti1-bM2b)zO?, characterized in that “x”, “y”, and “z” satisfy relations of x+y+z=1, 0.652?x/(x+y+z)?0.753, and 0.167?y/(y+z)?0.232; “a” is 0?a?1; “b” is 0?b?1; “?” is 0.8???1.2; “M1” is at least one selected from the group consisting of Sr, Na, Nd, Pr, Sm, Gd, Dy, Y, Eu, Tb, and Ba; and “M2” is at least one selected from the group consisting of Mg, W, Mn, Al, Ge, Ru, Nb, Ta, Co, Zr, Hf, Fe, Cr, and Ga.
Type:
Grant
Filed:
April 13, 2010
Date of Patent:
February 3, 2015
Assignee:
Toyota Jidosha Kabushiki Kaisha
Inventors:
Chihiro Yada, Hiroshi Suyama, Shoji Yokoishi, Brian Elliott Hayden, Thierry Le Gall, Duncan Clifford Alan Smith, Christopher Edward Lee