Abstract: The invention provides methods and articles for the administration of a biologically active substance (BAS). These methods and articles provide for the controlled and sustained delivery of relatively large quantities of these substances with a low burst effect. The articles made using the method of the invention have increased percentages (w/w) of macromer, increased crosslinking density, and reduced pore size in comparison to articles made using solution methods.

Abstract: Methods and apparatus are provided in which a coating is deposited onto a substrate by a process which includes the following steps: depositing a precursor onto the substrate in a desired pattern; depositing an appropriate ligand onto the substrate; and applying sufficient energy to transfer electrons from the ligand to the precursor, thereby decomposing the precursor to form a precipitate. In one aspect of preferred embodiments, the precursor comprises a metallic salt, and the precipitate comprises a metal. Especially preferred salts are carboxylates, halides, nitrates, and pseudo halides. In another aspect of preferred embodiments, the ligand comprises an amine, an amide, a phosphine, a sulfide, or any other ligand containing nitrogen, phosphorous, sulphur or other donor atoms. In another aspect of preferred embodiments, the energy is supplied at least partially as radiant heat.