Abstract: A system is provided for resolving data errors. The system is configured to receive a data element from a source application and process the data element using an Extract, Transform and Load (ETL) logic. Upon detecting that the processing of the data element has failed as a result of an error in the data element, the system generates a plurality of probable data values for the data element. For each probable data value of the plurality of probable data values, the system verifies whether the probable data value can be processed successfully by the ETL logic and by one or more target applications configured to process the data element. The system determines one of the probable data values as a suggested data value of the data element, based on the verification of the probable data values and processes the suggested data value using the ETL logic.

Abstract: A system is provided for resolving data errors. The system is configured to obtain an erroneous data element received from a source system and generate a plurality of probable data values for the data element. For each probable data value of the plurality of probable data values, the system verifies whether the probable data value can be processed successfully by an Extract, Transform and Load (ETL) logic and by one or more target applications configured to process the data element. The system determines one of the probable data values as a suggested data value of the data element, based on the verification of the probable data values. The system outputs the suggested data value for processing by the ETL logic.

Abstract: A system is provided for resolving data errors. The system is configured to receive a data element from a source application and process the data element using an Extract, Transform and Load (ETL) logic. Upon detecting that the processing of the data element has failed as a result of an error in the data element, the system generates a plurality of probable data values for the data element. For each probable data value of the plurality of probable data values, the system verifies whether the probable data value can be processed successfully by the ETL logic and by one or more target applications configured to process the data element. The system determines one of the probable data values as a suggested data value of the data element, based on the verification of the probable data values and processes the suggested data value using the ETL logic.

Abstract: A system is provided for resolving data errors. The system is configured to obtain an erroneous data element received from a source system and generate a plurality of probable data values for the data element. For each probable data value of the plurality of probable data values, the system verifies whether the probable data value can be processed successfully by an Extract, Transform and Load (ETL) logic and by one or more target applications configured to process the data element. The system determines one of the probable data values as a suggested data value of the data element, based on the verification of the probable data values. The system outputs the suggested data value for processing by the ETL logic.

Abstract: Aspects of the disclosure relate to dynamic transformation code prediction and generation for an unavailable data element. In some embodiments, a computing platform may execute an extract, transform, and load process on input data received from a plurality of data sources and detect a missing data element in the received input data. Subsequently, the computing platform may generate a prediction model with respect to the missing data element, which may include executing a first, second, and third machine learning algorithm. Next, the computing platform may determine a confidence level of the prediction model. In response to determining that the confidence level is at or above the predetermined threshold, the computing platform may generate executable transformation code implementing the prediction model.

Abstract: Aspects of the disclosure relate to dynamic transformation code prediction and generation for an unavailable data element. In some embodiments, a computing platform may execute an extract, transform, and load process on input data received from a plurality of data sources and detect a missing data element in the received input data. Subsequently, the computing platform may generate a prediction model with respect to the missing data element, which may include executing a first, second, and third machine learning algorithm. Next, the computing platform may determine a confidence level of the prediction model. In response to determining that the confidence level is at or above the predetermined threshold, the computing platform may generate executable transformation code implementing the prediction model.

Abstract: The present invention relates to the cationic lipid cordiaroimide hybrid compounds of formula I. The present invention provides a process for preparation of these compounds is also being elaborated. The compounds described provides anticancerous activity against cell lines including PC-3 (prostate cancer), HepG2 (liver cancer), MCF-7 (breast cancer) and NIH-1/3T3 (non cancer cells. The compound was also capable of inducing caspase-3 mediated apoptosis in HepG2 cells by arresting the cell cycle in the G1 phase. Furthermore, the compound exhibited DNA ligase I inhibition. The present class of cationic lipid cordiarimide hybrids is likely to find specific use in developing novel targeted therapies for liver and prostate cancers.

Abstract: The present invention relates to the cationic lipid cordiaroimide hybrid compounds of formula I. The present invention provides a process for preparation of these compounds is also being elaborated. The compounds described provides anticancerous activity against cell lines including PC-3 (prostate cancer), HepG2 (liver cancer), MCF-7 (breast cancer) and NIH-1/3T3 (non cancer cells. The compound was also capable of inducing caspase-3 mediated apoptosis in HepG2 cells by arresting the cell cycle in the G1 phase. Furthermore, the compound exhibited DNA ligase I inhibition. The present class of cationic lipid cordiarimide hybrids is likely to find specific use in developing novel targeted therapies for liver and prostate cancers.

Abstract: Present invention relates to an improved process for the preparation of Zopiclone and its enantiomerically enriched isomer (Eszopiclone). 6-(5-Chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine is reacted with 1-chloro-carbonyl-4-methylpiperazine in the presence of alkali earth metal carbonates, hydroxides or oxides in a solvent medium to give Zopiclone. It is reacted with optically active acid in a mixture of water and water miscible organic solvent followed by work up to give Eszopiclone. The present invention also relates to process for the conversion of (R) or (S) Zopiclone to 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydro-pyrrolo-[3,4-b]-pyrazine of the intermediate which can be converted to racemic Zopiclone.

Abstract: The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

Abstract: Present invention relates to an improved process for the preparation of Zopiclone and its enantiomerically enriched isomer (Eszopiclone). 6-(5-Chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine is reacted with 1-chloro-carbonyl-4-methylpiperazine in the presence of alkali earth metal carbonates, hydroxides or oxides in a solvent medium to give Zopiclone. It is reacted with optically active acid in a mixture of water and water miscible organic solvent followed by work up to give Eszopiclone. The present invention also relates to process for the conversion of (R) or (S) Zopiclone to 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydro-pyrrolo-[3,4-b]-pyrazine of the intermediate which can be converted to racemic Zopiclone.

Abstract: The present invention relates to novel Tenofovir disoproxil hemifumarate salt, which is prepared by dealkylation of Phosphonate esters by using mineral acids followed by esterification and crystallization to give crystalline Tenofovir disoproxil. The Tenofovir disoproxil is further converted to fumarate salts with improved yield.

Abstract: A catalyst assembly 16 for an exhaust gas system 14 for an automotive vehicle includes a housing 28 and a porous support structure 32 having a plurality of channels 34, 36. A plurality of catalyst pellets 50 are disposed within at least some of the channels. A retainer 54 is positioned adjacent to the support structure 32 for retaining the pellets 50 within the channels 34, 36.

Abstract: A catalyst assembly 16 for an exhaust gas system 14 for an automotive vehicle includes a housing 28 and a porous support structure 32 having a plurality of channels 34, 36. A plurality of catalyst pellets 50 are disposed within at least some of the channels. A retainer 54 is positioned adjacent to the support structure 32 for retaining the pellets 50 within the channels 34, 36.