Patents by Inventor Durgadas Bolikal

Durgadas Bolikal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11472918
    Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: October 18, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal, Julian Chesterman, Jarrod Cohen
  • Patent number: 11246884
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 15, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Publication number: 20220001073
    Abstract: Methods, copolymer materials and devices are provided for embolic arterial interventions (embolization therapy or embolotherapy). More particularly, radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapies, comprising copolymers of iodine-containing, halogenated phenyl-containing units, such as iodinated desaminotyrosine derivatives, and rubbery components, such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC), are provided. The provided microbeads may further contain, or be coated with, therapeutic agents such as paclitaxel, for targeted delivery of the therapeutics.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 6, 2022
    Inventors: Durgadas Bolikal, Lioubov Kabalnova, Ruth Sosa, Ernest G. Baluca, Jessica Earley, Joann Yao, Elizabeth Nesseler
  • Publication number: 20220002478
    Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
    Type: Application
    Filed: September 15, 2021
    Publication date: January 6, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20210380761
    Abstract: The present application provides polymer materials having the desired properties for implantation into a human or animal body, in particular, biocompatibility, biodegradability, radiopacity and mechanical properties. Methods of making such polymer materials, compositions or devices comprising such polymer materials, and uses of such polymer materials, compositions and devices are also disclosed.
    Type: Application
    Filed: August 7, 2019
    Publication date: December 9, 2021
    Inventors: Robert K. Schultz, Lioubov Kabalnova, Donald K. Brandom, Jessica Earley, Ernest G. Baluca, Durgadas Bolikal
  • Patent number: 11124603
    Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: September 21, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Patent number: 11118011
    Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: September 14, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20210040314
    Abstract: Methods of making multi-block copolymer that reduce the tendency for large phase domains to form provide copolymer compositions that are useful for various applications, including the manufacture of medical devices.
    Type: Application
    Filed: February 4, 2019
    Publication date: February 11, 2021
    Inventors: Lioubov Kabalnova, Durgadas Bolikal, Ernest G. Baluca, Jessica Earley
  • Publication number: 20200369597
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 26, 2020
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10774030
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbability and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 15, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10717810
    Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: July 21, 2020
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, REVA MEDICAL, INC.
    Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
  • Publication number: 20200181321
    Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20190292312
    Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
    Type: Application
    Filed: June 12, 2019
    Publication date: September 26, 2019
    Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
  • Patent number: 10329379
    Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogs, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: June 25, 2019
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, REVA MEDICAL, INC.
    Inventors: Durgadas Bolikal, Joachim B. Kohn, Lioubov Kabalnova
  • Publication number: 20190185624
    Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
    Type: Application
    Filed: January 4, 2019
    Publication date: June 20, 2019
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20190142863
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Application
    Filed: January 10, 2019
    Publication date: May 16, 2019
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10266647
    Abstract: Disclosed are monomeric compounds which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radiopacity and are useful for medical device applications and controlled release therapeutic formulations.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: April 23, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10206946
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: February 19, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10202490
    Abstract: The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: February 12, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Durgadas Bolikal
  • Publication number: 20190023644
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Application
    Filed: June 3, 2016
    Publication date: January 24, 2019
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Durgadas BOLIKAL, Joachim B. KOHN