Patents by Inventor Dusan GARIC

Dusan GARIC has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for enhancing ion transporter activity and uses thereof
    Patent number: 11510945
    Abstract: Methods for enhancing the activity of an ion transporter in a cell and/or treating a channelopathy in a subject based on the administration or use of an effective amount of a fenretinide compound (fenretinide, a fenretinide analog, or a pharmaceutically acceptable salt thereof) and/or zinc are described. The methods are useful for restoring or increasing the cell surface expression of an ion transporter such as the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that is mutated or defective. The fenretinide compound and/or zinc may be used in combination with ion transporter modulators, e.g., CFTR modulators, to further enhance the cell surface expression and activity of the ion transporter.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: November 29, 2022
    Assignee: THE ROYAL INSTITUTION FOR ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Danuta Radzioch, John Hanrahan, Asmahan Abu-Arish, Dusan Garic
  • COMPOSITIONS AND METHODS FOR ENHANCING ION TRANSPORTER ACTIVITY AND USES THEREOF
    Publication number: 20210100835
    Abstract: Methods for enhancing the activity of an ion transporter in a cell and/or treating a channelopathy in a subject based on the administration or use of an effective amount of a fenretinide compound (fenretinide, a fenretinide analog, or a pharmaceutically acceptable salt thereof) and/or zinc are described. The methods are useful for restoring or increasing the cell surface expression of an ion transporter such as the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that is mutated or defective. The fenretinide compound and/or zinc may be used in combination with ion transporter modulators, e.g., CFTR modulators, to further enhance the cell surface expression and activity of the ion transporter.
    Type: Application
    Filed: July 9, 2018
    Publication date: April 8, 2021
    Inventors: Danuta RADZIOCH, John HANRAHAN, Asmahan ABU-ARISH, Dusan GARIC