Patents by Inventor Dusan Hesoun

Dusan Hesoun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making ondansetron and intermediates thereof
    Patent number: 7041834
    Abstract: A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a water binding agent. The reaction product(s) can be reacted with an amine of formula (5) to form ondansetron.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: May 9, 2006
    Assignee: Synthon IP Inc.
    Inventors: Dusan Hesoun, Jiri Hykl
  • Process for making ondansetron and intermediates thereof
    Publication number: 20040181076
    Abstract: A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a water binding agent. The reaction product(s) can be reacted with an amine of formula (5) to form ondansetron. The water binding agent can improve the yield and/or speed of the reaction.
    Type: Application
    Filed: January 23, 2004
    Publication date: September 16, 2004
    Inventors: Dusan Hesoun, Jiri Hykl
  • 4-(3-Iodopropargyloxy) pyrimidine derivatives
    Patent number: 4384118
    Abstract: 4-(3-Iodopropargyloxy) pyrimidine derivatives of the general formula ##STR1## wherein R.sub.1 is selected from among a halogen atom, an amino group, a C.sub.1 -C.sub.4 alkylamino or a C.sub.1 -C.sub.4 alkylthio group, and R.sub.2 is selected from among a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or a C.sub.1 -C.sub.4 alkoxy group, are disclosed. The described compounds are prepared by reacting a 4-halopyrimidine with propargyl alcohol and iodinating the resultant product in the 3 position of the propargyl chain.
    Type: Grant
    Filed: June 15, 1981
    Date of Patent: May 17, 1983
    Assignee: SPOFA, spojene podniky pro zdravotnickou vyrobu
    Inventors: Dusan Hesoun, Bohumir Vondracek, Jana Turinova