Patents by Inventor Dustin COVELL

Dustin COVELL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-Alpha-Synuclein Monoclonal Antibodies, and Methods Using Same
    Publication number: 20230025707
    Abstract: The present disclosure provides in one aspect monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the disclosure provides a method of treating, ameliorating, and/or preventing ?-Synucleopathic disease in a subject, comprising administering any one of the antibodies of the disclosure to the subject. In yet other aspects, the disclosure provides methods of detecting ?-Synuclein fibrils using any one of the antibodies of the disclosure.
    Type: Application
    Filed: November 19, 2020
    Publication date: January 26, 2023
    Inventors: Kelvin C. Luk, Virginia M.Y. Lee, John Q. Trojanowski, Kurt R. Brunden, Dustin Covell
  • Monoclonal Antibodies Against Alpha-Synuclein Fibrils
    Publication number: 20220135661
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 5, 2022
    Inventors: Kelvin C. LUK, Virginia M.Y. LEE, John Q. TROJANOWSKI, Kurt R. BRUNDEN, Dustin COVELL
  • Monoclonal Antibodies Against Pathological Alpha-Synuclein, and Methods Using Same
    Publication number: 20220041698
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Inventors: Kelvin C. LUK, Virginia M.Y. LEE, John Q. TROJANOWSKI, Kurt R. BRUNDEN, Dustin COVELL
  • Monoclonal antibodies against alpha-synuclein fibrils
    Patent number: 11220538
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: January 11, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, Kurt R. Brunden, Dustin Covell
  • Monoclonal antibodies against pathological alpha-synuclein, and methods using same
    Patent number: 11155608
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 26, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, Kurt R. Brunden, Dustin Covell
  • Monoclonal Antibodies Against Pathological Alpha-Synuclein, and Methods Using Same
    Publication number: 20200369752
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Application
    Filed: August 22, 2018
    Publication date: November 26, 2020
    Inventors: Kelvin C. LUK, Virginia M.Y. LEE, John Q. TROJANOWSKI, Kurt R. BRUNDEN, Dustin COVELL
  • Monoclonal Antibodies Against Alpha-Synuclein Fibrils
    Publication number: 20200062835
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Application
    Filed: May 1, 2018
    Publication date: February 27, 2020
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Kelvin C. LUK, Virginia M.Y. LEE, John Q. TROJANOWSKI, Kurt R. BRUNDEN, Dustin COVELL