Patents by Inventor Dustin D. Armstrong

Dustin D. Armstrong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides
    Patent number: 9447394
    Abstract: The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalizing moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: September 20, 2016
    Assignee: Valerion Therapeutics, LLC
    Inventor: Dustin D. Armstrong
  • METHODS AND COMPOSITIONS FOR TREATMENT OF POMPE DISEASE
    Publication number: 20160108133
    Abstract: In certain embodiments, the present disclosure provides compositions and methods for treating Pompe disease.
    Type: Application
    Filed: February 20, 2014
    Publication date: April 21, 2016
    Inventors: Dustin D. Armstrong, Jeffrey C. Way
  • METHODS AND COMPOSITIONS FOR TREATMENT OF FORBES-CORI DISEASE
    Publication number: 20160089451
    Abstract: In certain embodiments, the present disclosure provides compositions and methods for treating Forbes-Cori Disease.
    Type: Application
    Filed: February 20, 2014
    Publication date: March 31, 2016
    Inventor: Dustin D. Armstrong
  • Methods and compositions for treatment of myotonic dystrophy
    Patent number: 9114178
    Abstract: In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: August 25, 2015
    Assignee: Valerion Therapeutics, LLC
    Inventor: Dustin D. Armstrong
  • METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTUBULAR MYOPATHY USING CHIMERIC POLYPEPTIDES COMPRISING MYOTUBULARIN 1(MTM1) POLYPEPTIDES
    Publication number: 20150218540
    Abstract: The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 6, 2015
    Inventor: Dustin D. Armstrong
  • METHODS FOR INCREASING MUSCLE CONTRACTILITY
    Publication number: 20150152170
    Abstract: The present disclosure provides methods for increasing muscle contractility in a myotubular myopathy subject following administration of fewer than 20 doses of a chimeric polypeptide that has a myotubularin protein and an internalizing moiety.
    Type: Application
    Filed: May 23, 2013
    Publication date: June 4, 2015
    Inventors: Dustin D. Armstrong, Michael O'Callaghan, Alan H. Beggs, Michael W. Lawlor
  • ANTISENSE CONJUGATES FOR DECREASING EXPRESSION OF DMPK
    Publication number: 20150064181
    Abstract: The disclosure provides novel conjugates comprising antisense oligonucleotides that hybridize to a DMPK transcript and a 3E10 antibody or binding fragment thereof. Also considered are these conjugates further comprising MBNL1 polypeptides. Methods of treating myotonic dystrophy using these conjugates and kits comprising these conjugates are also considered. Wherein the conjugates are suitable for delivery to muscle cells.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 5, 2015
    Applicant: VALERION THERAPEUTICS, LLC
    Inventor: Dustin D. Armstrong
  • Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides
    Patent number: 8834866
    Abstract: The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: September 16, 2014
    Assignee: Valerion Therapeutics, LLC
    Inventor: Dustin D. Armstrong
  • METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTONIC DYSTROPHY
    Publication number: 20140178377
    Abstract: In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 26, 2014
    Applicant: VALERION THERAPEUTICS, LLC
    Inventor: Dustin D. Armstrong
  • Methods and compositions for treatment of myotonic dystrophy
    Patent number: 8609615
    Abstract: In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: December 17, 2013
    Assignee: Valerion Therapeutics, LLC
    Inventor: Dustin D. Armstrong
  • METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTUBULAR MYOPATHY USING CHIMERIC POLYPEPTIDES COMPRISING MYOTUBULARIN 1(MTM1) POLYPEPTIDES
    Publication number: 20120213760
    Abstract: The present invention provides chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
    Type: Application
    Filed: June 15, 2010
    Publication date: August 23, 2012
    Applicant: 4s3 Bioscience Inc.
    Inventor: Dustin D. Armstrong
  • Methods and compositions for treatment of myotonic dystrophy
    Publication number: 20100111977
    Abstract: In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy.
    Type: Application
    Filed: October 15, 2009
    Publication date: May 6, 2010
    Applicant: 4s3 Bioscience Inc.
    Inventor: Dustin D. Armstrong