Patents by Inventor Dustin D. Hawker

Dustin D. Hawker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria
    Patent number: 11207283
    Abstract: Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum and malaria. The compounds disclosed herein are observed to selectively inactivate Toxoplasma gondii ornithine aminotransferase (TgOAT) relative to human OAT and relative to human ?-aminobutyric aminotransferase (GABA-AT).
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: December 28, 2021
    Assignees: Northwestern University, The University of Chicago
    Inventors: Richard B. Silverman, Hoang V. Le, Rima L. McLeod, Dustin D. Hawker
  • Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders
    Patent number: 10800753
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: October 13, 2020
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker
  • INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA
    Publication number: 20200281880
    Abstract: Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum and malaria. The compounds disclosed herein are observed to selectively inactivate Toxoplasma gondii ornithine aminotransferase (TgOAT) relative to human OAT and relative to human ?-aminobutyric aminotransferase (GABA-AT).
    Type: Application
    Filed: March 31, 2020
    Publication date: September 10, 2020
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Rima L. McLeod, Dustin D. Hawker
  • Inactivators of ornithine aminotransferase for treating toxoplasmosis and malaria
    Patent number: 10632088
    Abstract: Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum and malaria. The compounds disclosed herein are observed to selectively inactivate Toxoplasma gondii ornithine aminotransferase (TgOAT) relative to human OAT and relative to human ?-aminobutyric aminotransferase (GABA-AT).
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: April 28, 2020
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Rima L. McLeod, Dustin D. Hawker
  • Tetrahydrothiophene-based GABA Aminotransferase Inactivators and Analogs Thereof for Treating Neurological Disorders
    Publication number: 20190256489
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Application
    Filed: January 18, 2019
    Publication date: August 22, 2019
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker
  • ENCAPSULATED LAUNDRY CLEANING COMPOSITION
    Publication number: 20190085273
    Abstract: An encapsulated laundry cleaning composition includes a core cleaning composition and a water-soluble film disposed about the core cleaning composition. The core cleaning composition itself includes a detergent and a solvent system. The solvent system includes an ionic liquid and water. The water-soluble film has a disintegration time of less than 90 seconds as determined at 40° C. using distilled water according to MSTM 205, when disposed about the core cleaning composition.
    Type: Application
    Filed: March 8, 2017
    Publication date: March 21, 2019
    Inventors: Keith E. Gutowski, Dustin D. Hawker
  • Tetrahydrothiophene-based GABA aminotransferase inactivators
    Patent number: 10189807
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: January 29, 2019
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker
  • INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA
    Publication number: 20180098952
    Abstract: Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum and malaria. The compounds disclosed herein are observed to selectively inactivate Toxoplasma gondii ornithine aminotransferase (TgOAT) relative to human OAT and relative to human ?-aminobutyric aminotransferase (GABA-AT).
    Type: Application
    Filed: October 10, 2017
    Publication date: April 12, 2018
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Rima L. McLeod, Dustin D. Hawker
  • Tetrahydrothiophene-based GABA Aminotransferase Inactivators
    Publication number: 20180051001
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Application
    Filed: September 22, 2017
    Publication date: February 22, 2018
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker
  • Tetrahydrothiophene-based GABA aminotransferase inactivators
    Patent number: 9856231
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: January 2, 2018
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker
  • Tetrahydrothiophene-based GABA Aminotransferase Inactivators
    Publication number: 20160264544
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 15, 2016
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker