Patents by Inventor Dustin J. Maly

Dustin J. Maly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRE1? inhibitors and uses thereof
    Patent number: 11884649
    Abstract: Disclosed herein, inter alia, are compounds for inhibiting IRE1? and uses thereof.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: January 30, 2024
    Assignees: The Regents of the University of California, University of Washington
    Inventors: Feroz R. Papa, Bradley J. Backes, Dustin J. Maly
  • IRE1? inhibitors and uses thereof
    Patent number: 11840523
    Abstract: Disclosed herein, inter alia, are substituted quinazolin-2-amines and isoquinolin-3-amines for inhibiting IRE1? and uses thereof.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: December 12, 2023
    Assignees: The Regents of the University of California, University of Washington
    Inventors: Feroz R. Papa, Bradley J. Backes, Dustin J. Maly
  • Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
    Patent number: 11649237
    Abstract: Provided herein, inter alia, are substituted imidazo[1,5-?]pyrazine compounds, compositions and methods for treating or preventing an IRE1?-related disease or disorder. In certain embodiments, the disease or disorder is selected from the group consisting of a neurodegenerative disease, a demyelinating disease, cancer, an eye disease, a fibrotic disease, and diabetes.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: May 16, 2023
    Assignees: Optikira LLC, The Regents of the University of California
    Inventors: Richard M. Keenan, Bradley J. Backes, Dustin J. Maly, Charles Reynolds, Ben Whittaker, Jamie Knight, Jonathan Mark Sutton, George Hynd, Feroz R. Papa, Scott A. Oakes
  • Substituted imidazo[1,5-a]pyrazines for modulation of IRE1
    Patent number: 11613544
    Abstract: Described herein, inter alia, are certain substituted imidazo[1,5-a]pyrazines of formula (I) and methods of using the same for modulating the activity of Ire1.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: March 28, 2023
    Assignees: The Regents of the University of California, University of Washington Through Its Center For Commercialization
    Inventors: Bradley J. Backes, Dustin J. Maly, Scott A. Oakes, Feroz R. Papa, Gayani Perera, Likun Wang
  • IRE1ALPHA INHIBITORS AND USES THEREOF
    Publication number: 20220153723
    Abstract: Disclosed herein, inter alia, are compounds for inhibiting IRE1? and uses thereof.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 19, 2022
    Inventors: Feroz R. Papa, Bradley J. Backes, Dustin J. Maly
  • IRE1ALPHA INHIBITORS AND USES THEREOF
    Publication number: 20220153720
    Abstract: Disclosed herein, inter alia, are compounds for inhibiting IRE1? and uses thereof.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 19, 2022
    Inventors: Feroz R. Papa, Bradley J. Backes, Dustin J. Maly
  • IRE1 KINASE INHIBITORS AND USES THEREOF
    Publication number: 20210198238
    Abstract: Disclosed herein are, inter alia, compounds modulating Inositol-Requiring Enzyme 1? (IRE1?) and IRE1? activity and methods of use thereof for treating IRE1?-mediated and IRE1?-mediated disorders.
    Type: Application
    Filed: August 30, 2019
    Publication date: July 1, 2021
    Inventors: Bradley BACKES, Feroz R. PAPA, Scott Andre OAKES, Dustin J. MALY
  • MODULATION OF IRE1
    Publication number: 20210155626
    Abstract: Described herein, inter alia, are compositions and methods of using the same for modulating the activity of Ire1.
    Type: Application
    Filed: September 24, 2020
    Publication date: May 27, 2021
    Inventors: Bradley J. Backes, Dustin J. Maly, Scott A. Oakes, Feroz R. Papa, Gayani Perera, Likun Wang
  • COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION
    Publication number: 20200354367
    Abstract: The present invention provides novel compounds, compositions and methods for treating or preventing an IRE1?-related disease or disorder. In certain embodiments, the disease or disorder is selected from the group consisting of a neurodegenerative disease, a demyelinating disease, cancer, an eye disease, a fibrotic disease, and diabetes.
    Type: Application
    Filed: August 31, 2018
    Publication date: November 12, 2020
    Inventors: Richard M. Keenan, Bradley J. Backes, Dustin J. Maly, Charles Reynolds, Ben Whittaker, Jamie Knight, Jon Sutton, George Hynd, Feroz R. Papa, Scott A. Oakes
  • Substituted imidazolopyrazine compounds and methods of using same
    Patent number: 10822340
    Abstract: Described herein, inter alia, are certain substituted imidazolopyrazines of formula (I) and methods of using the same for modulating the activity of Ire1.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: November 3, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Bradley J. Backes, Dustin J. Maly, Scott A. Oakes, Feroz R. Papa, Gayani Perera, Likun Wang
  • MODULATION OF IRE1
    Publication number: 20190084989
    Abstract: Described herein, inter alia, are compositions and methods of using the same for modulating the activity of Ire1.
    Type: Application
    Filed: October 2, 2018
    Publication date: March 21, 2019
    Inventors: Bradley J. Backes, Dustin J. Maly, Scott A. Oakes, Feroz R. Papa, Gayani Perera, Likun Wang
  • Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1
    Patent number: 10131668
    Abstract: Described herein, inter alia, are compositions and methods of using the same for modulating the activity of Ire1 using for example, substituted imidazopyrazine compounds.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: November 20, 2018
    Assignees: The Regents of the University of California, University of Washington Through Its Center For Commercialization
    Inventors: Bradley J. Backes, Dustin J. Maly, Scott A. Oakes, Feroz R. Papa, Gayani Perera, Likun Wang
  • COMBINED MODULATION OF IRE1
    Publication number: 20170165259
    Abstract: Described herein, inter alia, are combined compositions of an Ire1 kinase modulating compound and an Ire1 ribonuclease modulating compound and methods of using the same.
    Type: Application
    Filed: December 21, 2016
    Publication date: June 15, 2017
    Inventors: Dustin J. MALY, Bradley J. Backes, Scott A. Oakes, Feroz R. Papa, Rajarshi Ghosh, Likun Wang
  • MODULATION OF IRE1
    Publication number: 20160024094
    Abstract: Described herein, inter alia, are compositions and methods of using the same for modulating the activity of Ire1.
    Type: Application
    Filed: March 26, 2015
    Publication date: January 28, 2016
    Inventors: Bradley J. Backes, Dustin J. Maly, Scott A. Oakes, Feroz R. Papa, Gayani Perera, Likun Wang