Patents by Inventor Dustin James MALY

Dustin James MALY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Pyrrolo- and Pyrazolo- Pyrimidines for Prostate Cancer Therapy
    Publication number: 20230125057
    Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases affected by glycolytic generation of adenosine triphosphate (ATP). More particularly, this disclosure relates to compounds and pharmaceutical compositions thereof, methods of selectively inhibiting glycolysis with these compounds, and methods of treating diseases that benefit from selective glycolysis inhibition, such as cancer.
    Type: Application
    Filed: January 7, 2021
    Publication date: April 20, 2023
    Inventors: Wesley C. VAN VOORHIS, Dustin James MALY, Kayode K. OJO, Gayani PERERA, Stephen R. PLYMATE, Cynthia SPRENGER, Takuma UO, Rama Subba Rao VIDADALA
  • Compositions and Methods for Treating Toxoplasmosis, Cryptosporidiosis and Other Apicomplexan Protozoan Related Diseases
    Publication number: 20190358231
    Abstract: The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R1, and R3 are defined herein.
    Type: Application
    Filed: May 2, 2019
    Publication date: November 28, 2019
    Inventors: Wilhelmus G.J. HOL, Eric T. LARSON, Dustin James MALY, Wesley C. VAN VOORHIS, Ethan MERRITT, Kayode K. OJO
  • BUMPED KINASE INHIBITOR COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20180271871
    Abstract: The present disclosure is generally directed to bumped kinase inhibitor (BKI) compositions and methods for treating cancer.
    Type: Application
    Filed: January 26, 2016
    Publication date: September 27, 2018
    Inventors: Wesley C. VAN VOORHIS, Erkang FAN, Dustin James MALY, Kayode K. OJO, Stephen R. PLYMATE, Rama Subba Rao VIDADALA
  • COMPOSITIONS AND METHODS FOR TREATING TOXOPLASMOSIS, CRYPTOSPORIDIOSIS AND OTHER APICOMPLEXAN PROTOZOAN RELATED DISEASES
    Publication number: 20180273537
    Abstract: The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R1, and R3 are defined herein.
    Type: Application
    Filed: January 26, 2016
    Publication date: September 27, 2018
    Inventors: Wilhelmus G.J HOL, Eric T. LARSON, Dustin James MALY, Wesley C. VAN VOORHIS, Ethan MERRITT, Kayode K. OJO
  • Compositions And Methods For Treating Toxoplasmosis, Cryptosporidiosis, And Other Apicomplexan Protozoan Related Diseases
    Publication number: 20130018040
    Abstract: Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R1, and R3 are defined herein.
    Type: Application
    Filed: July 30, 2012
    Publication date: January 17, 2013
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Wesley C. VAN VOORHIS, Wilhelmus G.J. HOL, Eric T. LARSON, Dustin James MALY, Ethan MERRITT, Kayode K. OJO