Patents by Inventor Dustin James Mergott

Dustin James Mergott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOW DOSE REGIMEN AND FORMULATION OF A 5-METHYL-1,2,4-OXADIAZOL-3-YL COMPOUND
    Publication number: 20230338349
    Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is administered orally with a total dose of the compound of 0.1 mg/day to 5 mg/day, useful for treating a neurodegenerative disease, including neurodegenerative tauopathies, such as Alzheimer's disease, frontotemporal dementia, corticobasilar syndrome, and progressive supranuclear palsy.
    Type: Application
    Filed: July 23, 2021
    Publication date: October 26, 2023
    Inventors: William Brian KIELBASA, Dustin James MERGOTT
  • COMBINATION THERAPY OF BACE-1 INHIBITOR AND ANTI-N3PGLU ABETA ANTIBODY
    Publication number: 20190365774
    Abstract: The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof in combination with an effective amount of an anti-N3pGlu Abeta antibody selected from the group consisting of hE8L, B12L, R17L, Antibody I, and Antibody II.
    Type: Application
    Filed: August 11, 2017
    Publication date: December 5, 2019
    Inventors: Dustin James Mergott, Brian Andrew Willis
  • 1,4-Oxazines useful as selective BACE1 inhibitors
    Patent number: 10399995
    Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, useful as a BACE1 inhibitor.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: September 3, 2019
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Erik James Hembre, II, Dustin James Mergott
  • Combination Therapy
    Publication number: 20190231791
    Abstract: The present invention provides a method of treating a cognitive or neu-rodegerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula (I):or a pharmaceutically acceptable salt thereof in combination with an effective amount of an anti-N3pGlu Abeta antibody selected from the group consisting of hE8L, B12L, R17L, Antibody I, and Antibody II.
    Type: Application
    Filed: October 13, 2017
    Publication date: August 1, 2019
    Inventors: Dustin James MERGOTT, Brian Andrew WILLIS
  • 1,4-OXAZINES USEFUL AS SELECTIVE BACE1 INHIBITORS
    Publication number: 20190161502
    Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, useful as a BACE1 inhibitor.
    Type: Application
    Filed: August 18, 2017
    Publication date: May 30, 2019
    Inventors: Steven James Green, Erik James Hembre, II, Dustin James Mergott
  • Combination Therapy
    Publication number: 20190046536
    Abstract: The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof in combination with an effective amount of an anti-N3pGlu Abeta antibody selected from the group consisting of hE8L, Antibody I, and Antibody II.
    Type: Application
    Filed: March 8, 2017
    Publication date: February 14, 2019
    Inventors: Ronald Bradley DeMattos, Dustin James Mergott, John Randall Sims, II
  • Combination Alzheimer therapy using anti-N3pGlu Abeta antibodies + a BACE inhibitor
    Patent number: 9999624
    Abstract: The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula I, or a pharmaceutically acceptable salt thereof; in combination with an effective amount of an anti-N3pGlu Abeta monoclonal antibody.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: June 19, 2018
    Assignee: Eli Lilly and Company
    Inventors: Patrick Cornelious May, Dustin James Mergott
  • COMBINATION ALZHEIMER THERAPY USING ANTI-N3PGLU ABETA ANTIBODIES + A BACE INHIBITOR
    Publication number: 20170224702
    Abstract: The present invention provides a method of treating a cognitive or neurodegenerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula I, or a pharmaceutically acceptable salt thereof; in combination with an effective amount of an anti-N3pGlu Abeta monoclonal antibody.
    Type: Application
    Filed: September 8, 2015
    Publication date: August 10, 2017
    Applicant: Eli Lilly and Company
    Inventors: Patrick Cornelious MAY, Dustin James MERGOTT
  • BACE inhibitors
    Patent number: 9328124
    Abstract: The present invention provides compounds of Formula I useful as BACE inhibitors in the treatment of e.g. Alzheimer's disease: wherein A is selected from the group consisting of; of; R1 is H or F; R2 is H, —OCH3, C1-C3 alkyl; R3 is H, —CH3, or —OCH3; and R4 is H or F; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: May 3, 2016
    Assignee: Eli Lilly and Company
    Inventors: Fionna Mitchell Martin, Dustin James Mergott, William Martin Owton
  • BACE inhibitors
    Patent number: 9169271
    Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 27, 2015
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Erik James Hembre, Dustin James Mergott, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • BACE INHIBITORS
    Publication number: 20150232483
    Abstract: The present invention provides compounds of Formula I useful as BACE inhibitors in the treatment of e.g. Alzheimer's disease: wherein A is selected from the group consisting of; of; R1 is H or F; R2 is H, —OCH3, C1-C3 alkyl; R3 is H, —CH3, or —OCH3; and R4 is H or F; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 17, 2013
    Publication date: August 20, 2015
    Inventors: Fionna Mitchell Martin, Dustin James Mergott, William Martin Owton
  • BACE INHIBITORS
    Publication number: 20150210716
    Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 30, 2015
    Inventors: Steven James GREEN, Erik James HEMBRE, Dustin James MERGOTT, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20150157641
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 19, 2015
    Publication date: June 11, 2015
    Inventors: Steven James GREEN, Dustin James MERGOTT, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • BACE inhibitors
    Patent number: 9029367
    Abstract: The present invention provides a compound of Formula III: Formula III wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof, which is useful for treating Alzheimer's disease.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: May 12, 2015
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Erik James Hembre, Dustin James Mergott, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8987254
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: March 24, 2015
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Dustin James Mergott, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • BACE INHIBITORS
    Publication number: 20140371212
    Abstract: The present invention provides a compound of Formula III: wherein A is: and Z, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 11, 2014
    Publication date: December 18, 2014
    Inventors: Steven James GREEN, Erik James HEMBRE, Dustin James MERGOTT, Yuan SHI, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20140350245
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: Steven James GREEN, Dustin James MERGOTT, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8889856
    Abstract: The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: November 18, 2014
    Assignee: Eli Lilly and Company
    Inventors: James Peter Beck, Steven James Green, Jose Eduardo Lopez, Brian Michael Mathes, Dustin James Mergott, Warren Jaye Porter, Zoran Rankovic, Yuan Shi, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • Tetrahydropyrrolothiazine compounds
    Patent number: 8841293
    Abstract: The present invention provides a compound of Formula I: Formula I wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: September 23, 2014
    Assignee: Eli Lilly and Company
    Inventors: Steven James Green, Dustin James Mergott, Brian Morgan Watson, Leonard Larry Winneroski, Jr.
  • TETRAHYDROPYRROLOTHIAZINE COMPOUNDS
    Publication number: 20140275044
    Abstract: The present invention provides a compound of Formula I: wherein R is H or F; and A is: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 18, 2014
    Applicant: Eli Lilly and Company
    Inventors: Steven James GREEN, Dustin James MERGOTT, Brian Morgan WATSON, Leonard Larry WINNEROSKI, JR.