Abstract: Described herein are methods and compositions related to treatments for cancer. Various embodiments relate to the determination of microsatellite instability as a marker for the likelihood of whether a given cancer will respond to certain therapies, including checkpoint inhibitor immunotherapies, and methods of treatment based upon those determinations.

Abstract: Methods, systems, and apparatus for tracking user clicks on result links in a search result webpage disclosed. In one aspect, a method includes generating one or more webpages each including a link to a destination document; specifying a style for the link in each webpage according to a style sheet language, the style including a behavior trigger indicating user selection of the link and a display property that causes retrieval of a resource from a remote server when the behavior trigger is activated; providing the webpages with the specified style to a plurality of clients; receiving at the remote server one or more requests from at least one of the plurality of clients for the resource; and in response to the receiving, recording a count for user selection of the destination document based on a number of received requests for the resource.

Abstract: Methods, systems, and apparatus for tracking user clicks on result links in a search result webpage disclosed. In one aspect, a method includes generating one or more webpages each including a link to a destination document; specifying a style for the link in each webpage according to a style sheet language, the style including a behavior trigger indicating user selection of the link and a display property that causes retrieval of a resource from a remote server when the behavior trigger is activated; providing the webpages with the specified style to a plurality of clients; receiving at the remote server one or more requests from at least one of the plurality of clients for the resource; and in response to the receiving, recording a count for user selection of the destination document based on a number of received requests for the resource.

Abstract: Methods, systems, and apparatus for tracking user clicks on result links in a search result webpage disclosed. In one aspect, a method includes generating one or more webpages each including a link to a destination document; specifying a style for the link in each webpage according to a style sheet language, the style including a behavior trigger indicating user selection of the link and a display property that causes retrieval of a resource from a remote server when the behavior trigger is activated; providing the webpages with the specified style to a plurality of clients; receiving at the remote server one or more requests from at least one of the plurality of clients for the resource; and in response to the receiving, recording a count for user selection of the destination document based on a number of received requests for the resource.

Abstract: Methods, systems, and apparatus for tracking user clicks on result links in a search result webpage disclosed. In one aspect, a method includes generating one or more webpages each including a link to a destination document; specifying a style for the link in each webpage according to a style sheet language, the style including a behavior trigger indicating user selection of the link and a display property that causes retrieval of a resource from a remote server when the behavior trigger is activated; providing the webpages with the specified style to a plurality of clients; receiving at the remote server one or more requests from at least one of the plurality of clients for the resource; and in response to the receiving, recording a count for user selection of the destination document based on a number of received requests for the resource.

Abstract: Methods, systems, and apparatus for tracking user clicks on result links in a search result webpage disclosed. In one aspect, a method includes generating one or more webpages each including a link to a destination document; specifying a style for the link in each webpage according to a style sheet language, the style including a behavior trigger indicating user selection of the link and a display property that causes retrieval of a resource from a remote server when the behavior trigger is activated; providing the webpages with the specified style to a plurality of clients; receiving at the remote server one or more requests from at least one of the plurality of clients for the resource; and in response to the receiving, recording a count for user selection of the destination document based on a number of received requests for the resource.

Abstract: A hole center marking system comprises a punch device and an alignment member. The punch device includes a body assembly and a punch movably disposed within the body assembly. The body assembly has a circular cross-sectional exterior shape at a first end portion thereof. An indenting tip portion of the punch is forcibly biased to a position within the body assembly adjacent the first end portion of the body assembly. The alignment member has a central bore configured for having the first end portion of the body assembly engaged therein. The central bore of the alignment member is size to provide a close-tolerance fit between the central bore and the first end portion of the body assembly.