Abstract: Methods and devices for eradicating biofilms and planktonic bacteria are provided. In on embodiment, a therapeutic delivery device comprised of at least a port and a antimicrobial releasing pouch and one or more therapeutic agents is provided to the mammal. In one aspect of at least one embodiment the releasing pouch has an internal reservoir comprised of a membrane that is configured to contain the one or more therapeutic agents that is to be administered to the mammal and the port is in fluid communication with the pouch and configured such that the pouch can be refilled with one or more therapeutic agents via the port. In other aspect of at least one embodiment the method is able to fully eradicate 109 colony forming units (CFU) of methicillin-resistant Staphylococcus aureus (MRSA) within a 24 hr period.

Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: A method of automating the collection, association, and coordination of multiple medical data sources using a coordinating service application, computer, database, and/or server system to manage devices, examinations, and people involved in the medical examination and treatment process. In an embodiment, the method comprises authenticating a user for a premises, a device, or a device group, validating particular use of the device based on user credentials or type of device or device group, associating a medical examination with a patient or a medical examination schedule, associating medical examination data from a device or device group with a related medical examination session, routing medical examination data to a computer, database, or server, and pairing medical examination session data with a medical interpretation, clinical testing results, diagnoses, and/or other recorded information.

Abstract: A method of automating the collection, association, and coordination of multiple medical data sources using a coordinating service application, computer, database, and/or server system to manage devices, examinations, and people involved in the medical examination and treatment process. In an embodiment, the method comprises authenticating a user for a premises, a device, or a device group, validating particular use of the device based on user credentials or type of device or device group, associating a medical examination with a patient or a medical examination schedule, associating medical examination data from a device or device group with a related medical examination session, routing medical examination data to a computer, database, or server, and pairing medical examination session data with a medical interpretation, clinical testing results, diagnoses, and/or other recorded information.

Abstract: A cathode of a battery including an electrolyte membrane, containing a first layer which contains 0.3 mg/cm2 or more and 9.0 mg/cm2 or less of a carbon catalyst; and a second layer which is arranged between the electrolyte membrane and the first layer in the battery, and which contains 0.002 mg/cm2 or more and 0.190 mg/cm2 or less of platinum. The carbon catalyst has a ratio of a mesopore volume to a total pore volume of 30% or more.

Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: A device for delivering one or more therapeutic agents to a mammal is provided. In at least one embodiment, the device includes (1) a port for receiving one or more therapeutic agents that is to be delivered to a mammal subcutaneously, the port having a stem; (2) a reservoir that is comprised of at least a compliant elastic material and a rate-controlling membrane that allows the one or more therapeutic agents to be delivered to the mammal at a controlled rate and the rate-controlling membrane and the compliant elastic material being attached to each other and the reservoir being capable of being inflated to contain one or more therapeutic agents and deflated, the reservoir being in fluid communication with the stem of the device.

Abstract: A method of automating the collection, association, and coordination of multiple medical data sources using a coordinating service application, computer, database, and/or server system to manage devices, examinations, and people involved in the medical examination and treatment process. In an embodiment, the method comprises authenticating a user for a premises, a device, or a device group, validating particular use of the device based on user credentials or type of device or device group, associating a medical examination with a patient or a medical examination schedule, associating medical examination data from a device or device group with a related medical examination session, routing medical examination data to a computer, database, or server, and pairing medical examination session data with a medical interpretation, clinical testing results, diagnoses, and/or other recorded information.

Abstract: A load sense pump can be used as a backup for a pressure-compensated pump in a wellbore operation. A pumping system can include a first pump, a second pump, a check valve, and a directional control valve. The first pump, which can be a load sense pump, can be used to provide pressure to a first hydraulic load. The second pump, which can be a pressure-compensated pump, can be used to provide pressure to a second hydraulic load. The directional control valve can be controllable to cause the first pump to change operation to provide pressure to the first hydraulic load and through the check valve to the second hydraulic load.

Abstract: A cathode of a battery including an electrolyte membrane, containing a first layer which contains 0.3 mg/cm2 or more and 9.0 mg/cm2 or less of a carbon catalyst; and a second layer which is arranged between the electrolyte membrane and the first layer in the battery, and which contains 0.002 mg/cm2 or more and 0.190 mg/cm2 or less of platinum. The carbon catalyst has a ratio of a mesopore volume to a total pore volume of 30% or more.

Abstract: A method of automating the collection, association, and coordination of multiple medical data sources using a coordinating service application, computer, database, and/or server system to manage devices, examinations, and people involved in the medical examination and treatment process. In an embodiment, the method comprises authenticating a user for a premises, a device, or a device group, validating particular use of the device based on user credentials or type of device or device group, associating a medical examination with a patient or a medical examination schedule, associating medical examination data from a device or device group with a related medical examination session, routing medical examination data to a computer, database, or server, and pairing medical examination session data with a medical interpretation, clinical testing results, diagnoses, and/or other recorded information.

Abstract: A rotary mixer includes a frame. The rotary mixer also includes a milling enclosure supported by the frame. The milling enclosure includes a side plate. The rotary mixer further includes a rotor disposed within the milling enclosure. The rotary mixer includes at least one vibration device coupled to the milling enclosure. The at least one vibration device is arranged to induce vibrations in at least one component of the milling enclosure for resisting accumulation of debris on the at least one component.

Abstract: The present invention is directed to a medical imaging binocular indirect ophthalmoscope with onboard sensor array and computational processing unit, enabling simultaneous or time-delayed viewing and collaborative review of photographs or videos from an eye examination. The invention also claims a method for photographing and integrating information associated with the images, videos, or other data generated from the eye examination.

Abstract: A cathode, a membrane electrode assembly, and a battery, each has excellent durability. The cathode is a cathode of a battery including an electrolyte membrane, the cathode including: a first layer which contains 0.3 mg/cm2 or more and 9.0 mg/cm2 or less of a carbon catalyst; and a second layer which is arranged between the electrolyte membrane and the first layer in the battery, and which contains 0.002 mg/cm2 or more and 0.190 mg/cm2 or less of platinum.

Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.

Abstract: A membrane electrode assembly including: an anode electrode; a cathode electrode; and a polymer electrolyte membrane; wherein the cathode includes a first cathode catalyst sublayer including a first precious metal catalyst composition and a first ionomer composition including a first ionomer and a second ionomer; and a second cathode catalyst sublayer including a second precious metal catalyst composition and a second ionomer composition including a third ionomer; wherein the first ionomer is different from the second ionomer in at least one of chemical structure and equivalent weight.

Abstract: A battery cathode, a composition for a catalyst layer of a battery cathode, and a battery, each achieves excellent performance while using a non-platinum catalyst. The battery cathode includes a catalyst layer, wherein the catalyst layer contains a non-platinum catalyst, has a thickness of 15 ?m or more, and has a conductance per 1 cm2 of an electrode area of more than 100 S and less than 350 S.

Abstract: The present invention is directed to a tool having a wrist mechanism that provides pitch and yaw rotation in such a way that the tool has no singularity in roll, pitch, and yaw. A positively positionable multi-disk wrist mechanism includes a plurality of disks or vertebrae stacked in series. Each vertebra is configured to rotate in pitch or in yaw with respect to each neighboring vertebra. Actuation cables are used to manipulate and control movement of the vertebrae. In specific embodiments, some of the cables are distal cables that extend from a proximal vertebra through one or more intermediate vertebrae to a distal vertebra, while the remaining cables are medial cables that extend from the proximal vertebra to one or more of the intermediate vertebrae. The cables are actuated by a pivoted plate cable actuator mechanism.