Patents by Inventor Duy H. Hua
Duy H. Hua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230279170Abstract: Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.Type: ApplicationFiled: March 2, 2023Publication date: September 7, 2023Inventor: Duy H. Hua
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Publication number: 20220349880Abstract: An electrochemical method for measuring the activity of biomarkers using microelectrode arrays functionalized with peptide consensus sequences and redox reporter moieties. Contact of the arrays with a biological sample containing one or more target biomarkers results in cleavage of the peptides and changes the electric current across the array in a quantifiable manner indicating not just the presence of the target biomarker in the sample, but its activity.Type: ApplicationFiled: April 26, 2022Publication date: November 3, 2022Inventors: Jun Li, Duy H. Hua, Morgan James Anderson, Jessica Erin Koehne, Meyya Meyyappan
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Publication number: 20220204447Abstract: Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The catalytic complexes have exhibited the ability to achieve reaction products have a very high degree of optical purifies. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.Type: ApplicationFiled: February 4, 2020Publication date: June 30, 2022Inventor: Duy H. Hua
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Patent number: 10906033Abstract: Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.Type: GrantFiled: March 28, 2017Date of Patent: February 2, 2021Assignee: Kansas State University Research FoundationInventor: Duy H. Hua
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Publication number: 20200306737Abstract: Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.Type: ApplicationFiled: March 28, 2017Publication date: October 1, 2020Inventor: Duy H. Hua
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Patent number: 9802962Abstract: Tricyclic pyrone compounds having high oral bioavailability, excellent blood-brain barrier permeability, and low toxicity are presented. Administration of the compounds to Alzheimer's Disease transgenic models resulted in substantially reduced soluble and insoluble A? species in the brain without affecting general behavior and motor coordination. Furthermore, in addition to blocking the toxicity and formation of both intraneuronal and extracellular A? aggregates, the compounds also increase cellular cholesterol efflux, restore axonal trafficking, and enhance hippocampal synaptic plasticity.Type: GrantFiled: September 30, 2014Date of Patent: October 31, 2017Assignees: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, AFASCI, INC.Inventors: Duy H Hua, Lee-way Jin, Izumi Maezawa, Xinmin Xie
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Publication number: 20150119406Abstract: Tricyclic pyrone compounds having high oral bioavailability, excellent blood-brain barrier permeability, and low toxicity are presented. Administration of the compounds to Alzheimer's Disease transgenic models resulted in substantially reduced soluble and insoluble A? species in the brain without affecting general behavior and motor coordination. Furthermore, in addition to blocking the toxicity and formation of both intraneuronal and extracellular A? aggregates, the compounds also increase cellular cholesterol efflux, restore axonal trafficking, and enhance hippocampal synaptic plasticity.Type: ApplicationFiled: September 30, 2014Publication date: April 30, 2015Inventors: Duy H. Hua, Lee-way Jin, Izumi Maezawa, Xinmin Xie
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Patent number: 8980951Abstract: Bicyclic sesquiterpene compounds exhibiting antifungal characteristics are formulated into antifungal compositions for use in the treatment of fungal infections in humans, animals, and plants. Particularly, sesquiterpene alcohols derived from drimane have been discovered to possess broad-spectrum antifungal characteristics. Exemplary antifungal sesquiterpene compounds include albicanol and drimenol, which have been shown effective against a number of pathogenic fungi.Type: GrantFiled: January 21, 2014Date of Patent: March 17, 2015Assignee: Kansas State University Research FoundationInventors: Govindsamy Vediyappan, Duy H. Hua
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Patent number: 8809368Abstract: This invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap junction disorders.Type: GrantFiled: October 28, 2008Date of Patent: August 19, 2014Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Dolores J. Takemoto, Thu Nguyen
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Publication number: 20140135404Abstract: Bicyclic sesquiterpene compounds exhibiting antifungal characteristics are formulated into antifungal compositions for use in the treatment of fungal infections in humans, animals, and plants. Particularly, sesquiterpene alcohols derived from drimane have been discovered to possess broad-spectrum antifungal characteristics. Exemplary antifungal sesquiterpene compounds include albicanol and drimenol, which have been shown effective against a number of pathogenic fungi.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Applicant: Kansas State University Research FoundationInventors: Govindsamy Vediyappan, Duy H. Hua
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Patent number: 7935726Abstract: Provided are compounds of formula IA or IB: wherein R1 and R8 are independently optionally substituted hydrocarbyl groups; wherein (a) R1 contains a carbonyl group and a phenyl group, (b) R8 contains an optionally substituted adenine group, or (c) R8 contains an alkenyl group with from two to six carbon atoms; R10 is H, —OH, —OR or ?O; R6 is selected from the group consisting of: H, OH, alkyl, alkenyl, alkynyl, an aromatic ring system, amino, sulfhydryl, sulfonyl, NH2 and OCOR; R2 is selected from the group consisting of: H, —OH and lower alkyl; R is H or an optionally substituted hydrocarbyl group, and pharmaceutically acceptable salts or esters of the foregoing, as well as isomers thereof.Type: GrantFiled: April 29, 2004Date of Patent: May 3, 2011Assignee: Kansas State University Research FoundationInventor: Duy H. Hua
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Publication number: 20110008304Abstract: The present invention is related to the use of cells, such as stem cells or immune system cells, to deliver nanogels comprising an active agent to a desired site in the body. The present invention utilizes cells as a delivery system for active agents that are difficult to deliver, such as active agents with poor solubility, that degrade easily, or that are toxic to the body. The nanogels are preferably non-toxic and can optionally include a lytic agent to program apoptosis of the cell to deliver the nanogel and active agent to a desired sire within the body.Type: ApplicationFiled: July 9, 2008Publication date: January 13, 2011Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Deryl Troyer, Duy H. Hua
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Publication number: 20100222432Abstract: Methods to prepare synthetic carbon nanotubes having controllable properties and synthetic carbon nanotubes having controllable properties are provided. The properties which are controllable using the methods provided here include independently and in combination: diameter, length, identity and number of functional groups present and identity and number of heteroatoms present.Type: ApplicationFiled: August 10, 2006Publication date: September 2, 2010Inventor: Duy H. Hua
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Publication number: 20090143425Abstract: This invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap junction disorders.Type: ApplicationFiled: October 28, 2008Publication date: June 4, 2009Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Duy H. HUA, Dolores J. TAKEMOTO, Thu NGUYEN
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Patent number: 6916824Abstract: Water-soluble, cell permeable aldose reductase inhibitors are presented. These compounds prevent the effects of galactosemia in patients. The compounds prevent both the accumulation of polyols and the change in levels of protein kinase C gamma observed during diabetes and galactosemia.Type: GrantFiled: November 13, 2000Date of Patent: July 12, 2005Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Dolores J. Takemoto, Alan Brightman, Bradley W. Fenwick
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Patent number: 6727277Abstract: A class of novel compounds is described for use in affecting lymphatic absorption of cholesterol. Compounds of particular interest are defined by Formula I: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 12, 2002Date of Patent: April 27, 2004Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Sung I. Koo, Sang K. Noh
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Patent number: 6384045Abstract: This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple condensation reaction of pyrones with cyclohexenecarboxaldehydes, providing high yields and using few steps. The tetracyclic oxypyrone synthetic method is a simple condensation reaction of carvones with pyrones.Type: GrantFiled: June 24, 1999Date of Patent: May 7, 2002Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Jean-Pierre Perchellet
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Patent number: 5958970Abstract: This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple condensation reaction of pyrones with cyclohexenecarboxaldehydes, providing high yields and using few steps. The tetracyclic oxypyrone synthetic method is a simple condensation reaction of carvones with pyrones.Type: GrantFiled: July 29, 1997Date of Patent: September 28, 1999Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Jean-Pierre Perchellet