Abstract: Flexible, insertable, transparent microelectrode arrays that allow integration of electrophysiological recordings with any optical imaging or stimulation technology are disclosed. In some embodiments of the disclosed technology, a microelectrode array includes a flexible substrate layer including a shank member extending in a first direction and a tapered tip at an end of the shank member, and a plurality of electrode wires arranged in the first direction on the flexible substrate layer, wherein the plurality of electrode wires includes adjacent electrode wires having different lengths from each other such that an electrode wire arranged closer to a centerline of the flexible substrate layer is longer than an adjacent electrode arranged further away from the centerline of the flexible substrate.

Abstract: Methods and devices for computationally constructing brain potentials across whole brain using electrocorticography signals recorded from a small region on the brain surface are disclosed. In some embodiments of the disclosed technology, a method includes obtaining a plurality of locally recorded surface potentials from a plurality of first cortical areas of a brain surface; and performing a virtual reconstruction of an average brain activity for individual cortical areas and a pixel-level cortex-wide brain activity for a plurality of cortical areas of the brain surface including the plurality of first cortical areas based on the plurality of locally recorded surface potentials.

Abstract: An implantable electrode for use in the body of a subject has a metal layer and a graphene passivation layer formed on at least a portion of the metal layer. The graphene passivation layer may be a single monolayer of graphene. A process for passivating an implantable electrode is also disclosed.

Abstract: A flexible, optically transparent electrode array comprises at least one graph electrode. The electrode may be positioned on a substrate. The flexible, optically transparent electrode may be used for simultaneous optical imaging and electrophysiological monitoring.

Abstract: A flexible, optically transparent electrode array comprises at least one graph electrode. The electrode may be positioned on a substrate. The flexible, optically transparent electrode may be used for simultaneous optical imaging and electrophysiological monitoring.

Abstract: An implantable electrode for use in the body of a subject has a metal layer and a graphene passivation layer formed on at least a portion of the metal layer. The graphene passivation layer may be a single monolayer of graphene. A process for passivating an implantable electrode is also disclosed.