Patents by Inventor Dvora Teitelbaum

Dvora Teitelbaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS
    Publication number: 20150030560
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 29, 2015
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
  • Copolymer-1 improvements in compositions of copolymers
    Patent number: 8367605
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 5, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • COPOLYMER-1 IMPROVEMENTS IN COMPOSITIONS OF COPOLYMERS
    Publication number: 20120077754
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 29, 2012
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Treatment of autoimmune conditions with Copolymer 1 and related copolymers
    Publication number: 20100298227
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Application
    Filed: August 29, 2008
    Publication date: November 25, 2010
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
  • Copolymer-1 improvements in compositions of copolymers
    Patent number: 7625861
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: December 1, 2009
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Treatment of autoimmune conditions with Copolymer 1 and related Copolymers
    Patent number: 7425332
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: September 16, 2008
    Assignees: Yeda Research and Development Co., Ltd., President and Fellows of Harvard University
    Inventors: Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger, Rina Aharoni, Dvora Teitelbaum, Ruth Arnon
  • Treatment of autoimmune conditions with copolymer 1 and related copolymers
    Patent number: 7279172
    Abstract: The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a subject for an autoimmune or an inflammatory disease, the heteropolymer compositions made by solid state synthesis. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: October 9, 2007
    Assignees: Yeda Research and Development Co., Ltd., President and Fellows of Harvard College
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
  • Copolymer-1 improvements in compositions of copolymers
    Publication number: 20070117757
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Application
    Filed: January 23, 2007
    Publication date: May 24, 2007
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Patent number: 7199098
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: April 3, 2007
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Treatment of autoimmune conditions with Copolymer 1 and related Copolymers
    Publication number: 20070021341
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Application
    Filed: September 27, 2006
    Publication date: January 25, 2007
    Inventors: Michael Sela, Masha Fridkis-Hareli, Jack Strominger, Rina Aharoni, Dvora Teitelbaum, Ruth Arnon
  • Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating GVHD and HVGD
    Patent number: 7053043
    Abstract: Compositions and methods for treating and preventing host-versus-graft disease and graft-versus-host disease comprising as active ingredient random copolymers of amino acids comprising one amino acid from at least three of the following groups: (a) lysine and arginine; (b) glutamic acid and aspartic acid; (c) alanine and glycine; and (d) tyrosine and tryptophan; with the proviso that the random copolymer is not Copolymer 1 or D-Copolymer 1 when the disease being treated is graft-versus-host disease.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: May 30, 2006
    Assignee: Yeda Research and Development Co.Ltd.
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Patent number: 6939539
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 6, 2005
    Assignee: Yeda Research & Development
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Publication number: 20050171286
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Application
    Filed: April 5, 2005
    Publication date: August 4, 2005
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Publication number: 20040106554
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Application
    Filed: July 10, 2003
    Publication date: June 3, 2004
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Patent number: 6620847
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: September 16, 2003
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Publication number: 20030064914
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Application
    Filed: December 14, 2001
    Publication date: April 3, 2003
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Treatment of autoimmune conditions with copolymer 1 and related copolymers
    Publication number: 20020055466
    Abstract: The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
    Type: Application
    Filed: January 23, 2001
    Publication date: May 9, 2002
    Inventors: Rina Aharoni, Dvora Teitelbaum, Ruth Arnon, Michael Sela, Masha Fridkis-Hareli, Jack L. Strominger
  • Copolymer-1 improvements on compositions of copolymers
    Patent number: 6362161
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: March 26, 2002
    Assignee: Yeda Research & Development Company Limited
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Copolymer-1 improvements in compositions of copolymers
    Patent number: 6342476
    Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: January 29, 2002
    Assignee: Yeda Research & Development Company Limited
    Inventors: Eliezer Konfino, Michael Sela, Dvora Teitelbaum, Ruth Arnon
  • Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1
    Patent number: 6214791
    Abstract: The present invention relates to the treatment of multiple sclerosis by ingestion or inhalation of copolymet-1 and pharmaceutical compositions useful for such treatment.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: April 10, 2001
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ruth Arnon, Michael Sela, Dvora Teitelbaum, Adrian Gilbert, Milka Linenberg, Rivka Riven-Kreitmann