Patents by Inventor Dvorah Diminsky

Dvorah Diminsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carotenoid-loaded liposomes
    Patent number: 7048943
    Abstract: The present invention is based on a novel method for encapsulating in liposomes substantially water immiscible carotenoids. Therefore, there are provided by the present invention formulations comprising liposomes loaded with an amount of at least one water immiscible carotenoid, pharmaceutical compositions comprising such a formulation, and a method for preparing the liposomes loaded with said carotenoid.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: May 23, 2006
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Yeckezkel Barenholz, Dvorah Diminsky, Rivka Cohen
  • Delivery of immunogenic molecules vis HBsAg particles
    Patent number: 7029680
    Abstract: Compositions of HBsAg particles having biologically active molecules contained in the particles, and methods of their use, e.g. in stimulating enhanced immune responses, are described. Antigenic peptides contained in HBsAg particles were found to produce a CTL response where none was elicited by the peptide alone. Encapsulation of immunostimulating molecules, such as cytokines, greatly enhanced the CTL response evoked by the HBsAg particles themselves.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: April 18, 2006
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Jörg Reimann, Yechezkel Barenholz, Dvorah Diminsky, Reinhold Schirmbeck
  • Carotenoid-loaded liposomes
    Publication number: 20030059462
    Abstract: The present invention is based on a novel method for encapsulating in liposomes substantially water immiscible carotenoids. Therefore, there are provided by the present invention formulations comprising liposomes loaded with an amount of at least one water immiscible carotenoid, pharmaceutical compositions comprising such a formulation, and a method for preparing the liposomes loaded with said carotenoid.
    Type: Application
    Filed: February 13, 2002
    Publication date: March 27, 2003
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY
    Inventors: Yeckezkel Barenholz, Dvorah Diminsky, Rivka Cohen
  • Method for high loading of vesicles with biopolymeric substances
    Patent number: 6156337
    Abstract: A method for loading liposomes with biopolymeric substances functional in humans involves combining a physiologically compatible solution of the biopolymeric substances with one or more dry, liposome-forming lipids, effecting a lipid-containing fraction, combining the lipid-containing fraction with an organic solvent, effecting an organic solvent fraction, and drying the organic solvent fraction, which effects a dry fraction of liposomes loaded with the biopolymeric substances.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: December 5, 2000
    Assignee: Opperbas Holding B.V.
    Inventors: Yechezkel Barenholz, Israel Nur, Lilianne K. Bar, Dvorah Diminsky, Moshe Baru
  • Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
    Patent number: 6066331
    Abstract: A composition useful for preparing vesicles loaded with biological cell-structures, biopolymers and/or -oligomers is prepared by solubilizing amphiphatic material such as a phospholipid in a polar-protic solvent miscible with water, solubilizing biological cell-structures, biopolymers and/or -oligomers in an aqueous medium, mixing the polar-protic solvent containing the amphiphatic material with the aqueous medium containing the biological cell-structures, biopolymers and/or -oligomers, and lyophilizing the resultant mixture to form a dry product. The dry product is hydrated in an aqueous medium to form the loaded vesicles. The polar-protic solvent may be tert-butanol, and the aqueous medium may contain a salt such as sodium chloride, an isoosmotic cryoprotectant such as lactose, sucrose or trehalose, or a mixture of the salt and the cryoprotectant. A medicament for disease treatment is formed by mixing the loaded vesicles with a pharmaceutically acceptable vehicle.
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: May 23, 2000
    Inventors: Yechezkel Barenholz, Lilianne K. Bar, Dvorah Diminsky, Moshe Baru