Patents by Inventor Dwayne L. Dunaway

Dwayne L. Dunaway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical compositions and methods of using same
    Patent number: 12209275
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: January 28, 2025
    Assignee: Bruker Spatial Biology, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • Chemical compositions and methods of using same
    Patent number: 12049666
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: September 21, 2023
    Date of Patent: July 30, 2024
    Assignee: Bruker Spatial Biology, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • Chemical compositions and methods of using same
    Patent number: 11821026
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: November 21, 2023
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
    Patent number: 11708602
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: July 25, 2023
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
  • Chemical compositions and methods of using same
    Patent number: 11279969
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: March 22, 2022
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
    Patent number: 10640816
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: May 5, 2020
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
  • Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
    Patent number: 10501777
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: December 10, 2019
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Gordon Mills, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder
  • Chemical compositions and methods of using same
    Patent number: 10415080
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 17, 2019
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • Protein detection via nanoreporters
    Patent number: 9995739
    Abstract: The invention provides methods, compositions, kits and devices for the detection of proteins. In some embodiments, the invention allows for multiplexed protein detection.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: June 12, 2018
    Assignee: NanoString Technologies, Inc.
    Inventor: Dwayne L. Dunaway
  • Methods for detection and quantification of analytes in complex mixtures
    Patent number: 9920380
    Abstract: The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of producing a population of uniquely labeled nucleic acid probes. Also provided is a method of detecting a nucleic acid analyte. The method consists of (a) contacting a mixture of nucleic acid analytes under conditions sufficient for hybridization with a plurality of target specific nucleic acid probes each having a different specifier; (b) contacting the mixture under conditions sufficient for hybridization with a corresponding plurality of anti-genedigits each having a unique label, the plurality of anti-genedigits having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) uniquely detecting a hybridized complex between one or more analytes in the mixture, a target specific probe, and an anti-genedigit.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 20, 2018
    Assignee: The Institute for Systems Biology
    Inventors: Krassen M. Dimitrov, Dwayne L. Dunaway
  • Protein detection via nanoreporters
    Patent number: 9714937
    Abstract: The invention provides methods, compositions, kits and devices for the detection of proteins. In some embodiments, the invention allows for multiplexed protein detection.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: July 25, 2017
    Assignee: NanoString Technologies, Inc.
    Inventor: Dwayne L. Dunaway
  • PROTEIN DETECTION VIA NANOREPORTERS
    Publication number: 20160003809
    Abstract: The invention provides methods, compositions, kits and devices for the detection of proteins. In some embodiments, the invention allows for multiplexed protein detection.
    Type: Application
    Filed: July 30, 2015
    Publication date: January 7, 2016
    Inventor: Dwayne L. Dunaway
  • Compositions comprising oriented, immobilized macromolecules and methods for their preparation
    Patent number: 8986926
    Abstract: The present invention provides methods and compositions that facilitate the identification of structures of a variety of macromolecules. For instance, the present invention provides methods for the selective immobilization of macromolecules in an extended or oriented state. The present invention also provides compositions comprising macromolecules selectively immobilized in extended or oriented states.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: March 24, 2015
    Assignee: NanoString Technologies, Inc.
    Inventors: Sean M. Ferree, Dwayne L. Dunaway
  • Methods for detection and quantification of analytes in complex mixtures
    Patent number: 8492094
    Abstract: The invention provides a method of detecting a nucleic acid analyte. The method consists of (a) contacting a mixture of nucleic acid analytes under conditions sufficient for hybridization with a plurality of target specific nucleic acid probes each having a different specifier; (b) contacting the mixture under conditions sufficient for hybridization with a corresponding plurality of antigenedigits each having a unique label, the plurality of anti-genedigits having a diversity sufficient to uniquely hybridize to genedigits within the specifiers, and (c) uniquely detecting a hybridized complex between one or more analytes in the mixture, a target specific probe, and an anti-genedigit.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: July 23, 2013
    Assignee: The Institute for Systems Biology
    Inventors: Krassen Dimitrov, Dwayne L. Dunaway
  • Protein Detection Via Nanoreporters
    Publication number: 20110086774
    Abstract: The invention provides methods, compositions, kits and devices for the detection of proteins. In some embodiments, the invention allows for multiplexed protein detection.
    Type: Application
    Filed: October 13, 2010
    Publication date: April 14, 2011
    Inventor: Dwayne L. Dunaway
  • Compositions comprising oriented, immobilized macromolecules and methods for their preparation
    Publication number: 20100261026
    Abstract: The present invention provides methods and compositions that facilitate the identification of structures of a variety of macromolecules. For instance, the present invention provides methods for the selective immobilization of macromolecules in an extended or oriented state. The present invention also provides compositions comprising macromolecules selectively immobilized in extended or oriented states.
    Type: Application
    Filed: December 22, 2006
    Publication date: October 14, 2010
    Inventors: Sean M. Ferree, Dwayne L. Dunaway