Patents by Inventor Dwight A. Towler

Dwight A. Towler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7060463
    Abstract: The present invention discloses the isolation and characterization of cDNA molecules encoding novel androgen receptor (AR) protein from Macaca mulatta. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of Macaca mulatta AR (rhAR) activity, purified proteins and fusion proteins which comprise all or a portion of the rhAR protein, transgenic mice comprising a transgene encoding the rhAR protein, as well as production of antibodies against AR, or epitopes thereof.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: June 13, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Dwight A. Towler, Fang Chen
  • Publication number: 20040254105
    Abstract: The present invention discloses the isolation and characterization of cDNA molecules encoding novel androgen receptor (AR) protein from Macaca mulatta. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of Macaca mulatta AR (rhAR) activity, purified proteins and fusion proteins which comprise all or a portion of the rhAR protein, transgenic mice comprising a transgene encoding the rhAR protein, as well as production of antibodies against AR, or epitopes thereof.
    Type: Application
    Filed: October 31, 2003
    Publication date: December 16, 2004
    Inventors: Dwight A. Towler, Fang Chen
  • Patent number: 6645974
    Abstract: Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, arthritis and joint repair, alone or in combination with other active agents.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: November 11, 2003
    Assignee: Merck & Co., Inc.
    Inventors: John H. Hutchinson, Michael J. Breslin, Gideon A. Rodan, Soumya P. Sahoo, Mark E. Duggan, Shun-Ichi Harada, Azriel Schmidt, Wasyl Halczenko, Dwight A. Towler
  • Publication number: 20030065004
    Abstract: Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, arthritis and joint repair, alone or in combination with other active agents.
    Type: Application
    Filed: July 25, 2002
    Publication date: April 3, 2003
    Inventors: John H. Hutchinson, Michael J. Breslin, Gideon A. Rodan, Soumya P. Sahoo, Mark E. Duggan, Shun-Ichi Harada, Azriel Schmidt, Wasyl Halczenko, Dwight A. Towler
  • Patent number: 4778878
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 18, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Jeffrey I. Gordon
  • Patent number: 4778877
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 18, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Jeffrey I. Gordon
  • Patent number: 4740588
    Abstract: A peptide substrate for myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Ala, Asn, Gln or Ser;S=Ala, Arg, Gln, Glu, Phe or Ser;T=Ala or Lys;W=Ala or Ser;X=Ala, Tyr, or Lys;Y=Arg or Pro; andZ=Arg, Leu or Lys.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: April 26, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Luis Glaser
  • Patent number: 4709012
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Leu, Phe, Tyr or Val.
    Type: Grant
    Filed: August 7, 1986
    Date of Patent: November 24, 1987
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Luis Glaser