Patents by Inventor Dwight E. Raff

Dwight E. Raff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same
    Patent number: 6300503
    Abstract: Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trials as an anti-hypertensive. Omapatrilat may be synthesized using the S-stereoisomer of compound (V). Compound (V) may be prepared from a novel hydantoin (III). The hydantoin may be prepared from a monoacetal (XI) or via a dinitrile (V).
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: October 9, 2001
    Assignee: Dixie Chemical Company
    Inventors: Joseph C. Rongione, Robert E. Brown, Dwight E. Raff
  • Dinitrile intermediates for the synthesis of omapatrilat and methods for producing same
    Patent number: 6284901
    Abstract: Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trials as an anti-hypertensive. Omapatrilat may be synthesized using the S-stereoisomer of a racemic mixture. The racemic mixture may be prepared from a hydantoin (III). The hydantoin may be prepared from a novel dinitrile compound (IV): The dinitrile may be produced by reacting a monoacetal with a non-carbonate ammonium salt and an alkali cyanide.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: September 4, 2001
    Assignee: Dixie Chemical Company
    Inventors: Joseph C. Rongione, Robert G. Brown, Dwight E. Raff