Patents by Inventor Dwight G. Nishimura

Dwight G. Nishimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6219571
    Abstract: A new technique for imaging a material with a high T2/T1 ratio such as articular cartilage uses driven equilibrium Fourier transform (DEFT), a method of enhancing signal strength without waiting for full T1 recovery. Compared to other methods, DEFT imaging provides a good combination of bright cartilage and high contrast between cartilage and surrounding tissue. Both theoretical predictions and images show that DEFT is a valuable method for imaging articular cartilage when compared to spoiled gradient recalled acquisition in the steady-state (SPGR) or fast spin echo (FSE). T2-decay, T1 recovery, echo time, magnetization density, proton density, and equilibrium density per proton are related by a derived equation.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 17, 2001
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Dwight G. Nishimura
  • Patent number: 5957843
    Abstract: Flyback imaging is combined with echo planar imaging (EPI) for improved readout flow properties. For increases in imaging time of 50% or less, significant improvements in imaging are realized. The partial flyback improves partial-Fourier EPI and inside-out EPI and can be applied to any EPI trajectory.
    Type: Grant
    Filed: August 14, 1995
    Date of Patent: September 28, 1999
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Gerard T. Luk Pat, Craig H. Meyer, John M. Pauly, Dwight G. Nishimura
  • Patent number: 5655531
    Abstract: The selective imaging of an object having two materials with different relaxation times (T1 or T2) is provided by using a driven equilibrium sequence (T2 weighted preparation sequence) followed by an inversion recovery sequence. In the driven equilibrium sequence the object is placed in a static magnetic field along a longitudinal axis, an excitation pulse is applied to tip nuclei spins into a transverse plane, and at least one refocusing pulse is applied to produce a spin echo having a magnetization component as a function of relaxation time. At least one pulse is then applied to the object to drive the spin echo to an inverted position along the longitudinal axis. A readout excitation is then applied at a later time when the longitudinal magnetization of one material is substantially reduced. In one embodiment, an inversion pulse is applied prior to the T2 weighted preparation sequence.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: August 12, 1997
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dwight G. Nishimura, Jean H. Brittain
  • Patent number: 5588431
    Abstract: Multiple inversion recovery flow imaging employs at least four spin inversion pulses following saturation of static nuclei spins to null nuclei in static material having different spin-lattice relaxation times (T.sub.1) with the inversion pulses being spaced in time to substantially reduce the longitudinal magnetization of the T.sub.1 species present. The saturation of static nuclei spins includes applying a sequence of saturation pulses with adjacent pulses being separated by a diphasing gradient to avoid refocusing coherence. The detection of signals includes applying at least one RF read-out pulse near the nulling point.
    Type: Grant
    Filed: August 17, 1995
    Date of Patent: December 31, 1996
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sanjay Mani, Dwight G. Nishimura, Steven M. Conolly, John M. Pauly
  • Patent number: 5427101
    Abstract: A method whereby motion can be detected in real time during the acquisition of MRI data. This enables the implementation of several algorithms to reduce or eliminate this motion from an image as it is being acquired. The method is an extension of the acceptance/rejection method algorithm called the diminishing variance algorithm (DVA). With this method, a complete set of preliminary data is acquired along with information about the relative motion position of each frame of data. After all the preliminary data is acquired, the position information is used to determine which lines are most corrupted by motion. Frames of data are then reacquired, starting with the most corrupted frame. The position information is continually updated in an iterative process, therefore each subsequent reacquisition is always done on the worst frame of data. The algorithm has been implemented on several different types of sequences, and preliminary in vivo studies indicate that motion artifacts are dramatically reduced.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: June 27, 1995
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Todd S. Sachs, Craig H. Meyer, Dwight G. Nishimura
  • Patent number: 5150053
    Abstract: Magnetic resonance signals for imaging species having short spin-spin relaxation times (T.sub.2) are obtained without the need for a refocusing lobe. A series of RF excitation pulses are applied to the species with magnetic resonance signals being detected after each RF excitation pulse is applied. The magnetic resonance signals are then combined to provide the imaging signals. In one embodiment, each RF excitation pulse is half of a conventional slice-selective pulse with each pulse being slewed to zero. Contrast between the imaged short T.sub.2 species and longer T.sub.2 species can be enhanced by first applying an RF signal having sufficient amplitude to excite the longer T.sub.2 species but insufficient amplitude to excite the short T.sub.2 species whereby the longer T.sub.2 species are tipped by the RF signal. A magnetic gradient can then be applied to dephase the tipped nuclei of the longer T.sub.2 species. The imaging signals are then obtained from magnetic resonance signals from the short T.sub.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: September 22, 1992
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John M. Pauly, Steven M. Conolly, Dwight G. Nishimura
  • Patent number: 5025216
    Abstract: Magnetic resonance signals for imaging species having short spin-spin relaxation times (T.sub.2) are obtained without the need for a refocusing lobe. A series of RF excitation pulses are applied to the species with magnetic resonance signals being detected after each RF excitation pulse is applied. The magnetic resonance signals are then combined to provide the imaging signals. In one embodiment, each RF excitation pulse is half of a conventional slice-selective pulse with each pulse being slewed to zero.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: June 18, 1991
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John M. Pauly, Dwight G. Nishimura
  • Patent number: 4993414
    Abstract: A two-dimensional projection image of the NMR activity within a volume is obtained. The signals due to static material are not excited and do not appear in the projection image. The signals due to moving blood in vessels produce an isolated image of the vessels with the superimposed structure removed. Excitation systems are used which excite only moving material and return static material to equilibrium.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: February 19, 1991
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Albert Macovski, Dwight G. Nishimura
  • Patent number: 4836209
    Abstract: A method of imaging material flowing through a slab in a body using magnetic resonance techniques includes placing the body in a magnetic field including a first magnetic (z) gradient for slab thickness selection. A first rf pulse (180.degree.) is applied to the body at a frequency band and of sufficient strength to flip nuclear spins located essentially in the slab. After allowing moving material in the slab to flow from the slab, a second rf (90.degree.) pulse is applied to the body at a frequency band of sufficient strength to flip the nuclear spins in the slab for generating a signal. First image date in an X-Z plane is obtained from the nuclear spins flipped by the second 90.degree. rf pulse. Thereafter, a third 180.degree. rf pulse is applied to the body. In one embodiment the third rf pulse is non-selective and is of sufficient strength to flip nuclear spins in the body including but not limited to the slab. Moving material is again allowed to flow from the slab, and a fourth 90.degree.
    Type: Grant
    Filed: May 11, 1988
    Date of Patent: June 6, 1989
    Assignee: Stanford University
    Inventor: Dwight G. Nishimura
  • Patent number: 4718424
    Abstract: Selective material projection imaging in which static and flowing material are distinguishable utilizes magnetic gradients whose waveforms have selective moments. The effects of the magnetic field gradients are utilized in obtaining data for a plurality of images whereby the subtraction of image data will result in selected material imaging. The zero moment of a magnetic gradient waveform affects the phase of static material and the phase of moving material, while the first moment of a magnetic gradient waveform affects the phase of constant velocity moving material but not the phase of static material. The second moment of a magnetic gradient waveform affects the phase of varying velocity moving material but not the phase of static material or constant velocity material. The nuclear spins of a region of a body can be excited under different conditions of an applied magnetic field gradient so that data under the different conditions can be subtracted to eliminate selected material.
    Type: Grant
    Filed: August 7, 1986
    Date of Patent: January 12, 1988
    Assignee: Stanford University
    Inventor: Dwight G. Nishimura
  • Patent number: 4672319
    Abstract: Improved nuclei excitation for NMR applications is provided by employing a sequence of RF pulses for exciting the nuclei. Non-linearities in pulse excitation are compensated by applying at least one additional RF pulse thereby improving slice definition and/or phase characteristics. In one application, one or more initial RF pulses establish an intermediate state for the nuclei from which the nuclei can be tilted to a final desired magnetic moment state by the application of a single RF pulse. The order of applying the magnetic pulses can be reversed when the flip/angle is 180 degrees.
    Type: Grant
    Filed: September 19, 1984
    Date of Patent: June 9, 1987
    Assignee: Stanford University
    Inventor: Dwight G. Nishimura
  • Patent number: 4503461
    Abstract: Extraneous signals or artifacts are reduced in a multiple measurement noise reducing system such as an X-ray imaging system by processing a plurality of measurements to obtain a first image signal of an object representing a desired parameter such as a blood vessel, processing the plurality of measurements to provide a second image signal having increased signal-to-noise, low pass filtering the first image signal, high pass filtering the second image signal, and then combining the two filtered signals. The filter frequencies are varied in response to the presence of artifacts to minimize effects of the artifact on the combined signal.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: March 5, 1985
    Assignee: The Board of Trustees of the Leland, Stanford Junior University
    Inventor: Dwight G. Nishimura
  • Patent number: 4499493
    Abstract: Disclosed is a multiple measurement multiple energy X-ray imaging system in which a plurality of measurements are processed to provide a first image signal representing a desired parameter of an object and in which the plurality of measurements are processed to provide a second processed image signal having greater signal-to-noise ratio than the first processed image signal but in which extraneous artifacts may be introduced into the signal. The spatial location of edges of the extraneous artifacts are determined. The first processed image signal and the second processed image signal are combined to provide an improved image signal except at the spatial locations of the extraneous artifacts where the first processed image signal is used for the image signal thereby eliminating the extraneous artifact from the displayed image.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: February 12, 1985
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Dwight G. Nishimura