Patents by Inventor Dwight Henninger
Dwight Henninger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10668104Abstract: Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.Type: GrantFiled: June 7, 2016Date of Patent: June 2, 2020Assignees: Ethicon Endo-Surgery, Inc., The General Hospital CorporationInventors: Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, Taylor W. Aronhalt, James W. Voegele
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Patent number: 10441459Abstract: Methods and devices are provided for activating brown adipose tissue (BAT) with cooling. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by cooling tissue having a high density of cold sensitive thermoreceptors and/or by cooling BAT depots directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure.Type: GrantFiled: December 21, 2011Date of Patent: October 15, 2019Assignees: Ethicon Endo-Surgery, Inc., The General Hospital CorporationInventors: Taylor W. Aronhalt, Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, James W. Voegele, Mark S. Ortiz
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Patent number: 10111770Abstract: Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.Type: GrantFiled: February 21, 2017Date of Patent: October 30, 2018Assignees: Ethicon Endo-Surgery, Inc., The General Hospital CorporationInventors: Jason L. Harris, Taylor W. Aronhalt, Dwight Henninger, James W. Voegele, Lee M. Kaplan, Nicholas Stylopoulos
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Publication number: 20170156907Abstract: Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.Type: ApplicationFiled: February 21, 2017Publication date: June 8, 2017Inventors: Jason L. Harris, Taylor W. Aronhalt, Dwight Henninger, James W. Voegele, Lee M. Kaplan, Nicholas Stylopoulos
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Patent number: 9610429Abstract: Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.Type: GrantFiled: December 21, 2011Date of Patent: April 4, 2017Assignees: Ethicon Endo-Surgery, Inc., The General Hospital CorporationInventors: Jason L. Harris, Taylor W. Aronhalt, Dwight Henninger, James W. Voegele, Lee M. Kaplan, Nicholas Stylopoulos
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Publication number: 20170000827Abstract: Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.Type: ApplicationFiled: June 7, 2016Publication date: January 5, 2017Inventors: Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, Taylor W. Aronhalt, James W. Voegele
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Patent number: 9381219Abstract: Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.Type: GrantFiled: December 21, 2011Date of Patent: July 5, 2016Assignees: Ethicon Endo-Surgery, Inc., The General Hospital CorporationInventors: Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, Taylor W. Aronhalt, James W. Voegele
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Publication number: 20140199278Abstract: Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.Type: ApplicationFiled: December 21, 2011Publication date: July 17, 2014Applicants: The General Hospital Corporation D/B/A Massachusetts General Hospital, ETHICON ENDO-SURGERY, INC.Inventors: Lee M. Kaplan, Nicholas Stylopoulos, Jason L. Harris, Dwight Henninger, Taylor W. Aronhalt, James W. Voegele
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Publication number: 20140018767Abstract: Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.Type: ApplicationFiled: December 21, 2011Publication date: January 16, 2014Applicants: The General Hospital Corporation D/B/A Massachusetts General Hospital, ETHICON ENDO-SURGERY, INC.Inventors: Jason L. Harris, Taylor W. Aronhalt, Dwight Henninger, James W. Voegele, Lee M. Kaplan, Nicholas Stylopoulos