Abstract: An instrument case and alarm is disclosed that provides a reliable alarm system that selectively uses audio, visual and radio alerts to attract attention to the case and instrument. In one preferred embodiment, the alarm emits a separate and distinct audible alarm if the instrument is removed from the case. The case comprises housing that protectively encloses the instrument. A door hinged mounts the housing to provide access therein. Several feet project from the housing to support the case. The alarm mounts inside the housing. A primary set switch penetrates the instrument case housing and the alarm frame. This primary switch is preferably key-operated. The switch sets the alarm. Preferably, my alarm has a selective down time. The alarm uses several triggers to sense detonation stimuli. The case trigger comprises two separately actuable sensor arrays. Preferably, at least one sensor on each array penetrates a case foot. Another trigger detects motions of the case. Another trigger detects case openings.