Abstract: The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.

Abstract: Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle.

Abstract: The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.

Abstract: Methods describing the use of nanoparticles modified with binding moieties are provided.

Abstract: The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.

Abstract: Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle.

Abstract: The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.

Abstract: Methods describing the use of nanoparticles modified with binding moieties are provided.

Abstract: Synthesis of gold microtubes and nanotubes suspendable in solution is presented. The synthesis is accomplished using an AAO template route, wherein a polymer tube is used as a sacrificial core. The synthesis produces hollow structures that consist of only gold. These nanostructures exhibit two SPR modes, which correspond to both the transverse and longitudinal modes. The mode assignment was confirmed by measuring SPR behavior as both aligned arrays and in solution. The performance of gold nanotubes as refractive index detectors was quantified and determined to be more sensitive than analogous solid nanorods prepared under identical conditions, and are among the most sensitive nanostructured plasmon sensors to date. Due to their intense and sensitive resonances in the NIR spectrum, these solution-suspendable nanoparticles have potential to be used as in vitro or in vivo sensors.

Abstract: The present disclosure is directed to compositions and methods for detecting or associating with a target polynucleotide.

Abstract: Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control.