Abstract: An improved endotracheal tube holder generally comprises an elliptically shaped base member having associated therewith an endotracheal tube stabilization mechanism, for fixing an endotracheal tube into a set position, and an appliance securing mechanism, for affixing the tube holder to a patient's head and/or neck. The tube holder is also provided with a plurality of alternately inflatable fluid chambers, perimetrically disposed about the lower circumference of the holder's base member and oriented for interposition between the base member and the patient's oral and/or facial regions. A source of pressurized fluid is provided for alternately inflating the fluid chambers according to the state of a provided selection device. The improved holder relieves the interface pressure between the base member and the patient's oral and/or facial regions created by the appliance securing mechanism.