Patents by Inventor Dylan Alexander

Dylan Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250027070
    Abstract: Provided in this disclosure are engineered sesquiterpene synthases, host cells expressing engineered sesquiterpene synthases and methods for making alpha-guaiene.
    Type: Application
    Filed: November 18, 2022
    Publication date: January 23, 2025
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Jeffrey Ian Boucher, Dylan Alexander Carlin, Cinzia Formighieri, Bryan Greenhagen, Jaide Jensen, Scott Marr
  • Publication number: 20240425841
    Abstract: Aspects of the disclosure relate to phenylalanine ammonia lyase (PAL) enzymes, including engineered PAL enzymes, and their use in catalyzing chemical reactions.
    Type: Application
    Filed: September 8, 2022
    Publication date: December 26, 2024
    Applicants: Ginkgo Bioworks, Inc., Synlogic Operating Company, Inc.
    Inventors: Dylan Alexander Carlin, Ariel Hecht, Vincent Isablella, Jonathan Lewis McMurry, Catherine Monahan, Nikos Reppas, Christan Ridley, Nathan W. Schmidt
  • Publication number: 20240141308
    Abstract: Aspects of the disclosure relate to phosphotriesterase (PTE) enzymes and PTE-related (PTER) enzymes and their use in hydrolyzing OPNAs.
    Type: Application
    Filed: April 15, 2022
    Publication date: May 2, 2024
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: David Borhani, Dylan Alexander Carlin, Alex Tucker
  • Publication number: 20240110206
    Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Specifically, the disclosure is directed to a prenyltransferase variant, a chimeric prenyltransferase comprising one or more portions of at least two different prenyltransferase proteins, and a fusion polypeptide comprising a CBG-type producing prenyltransferase and farnesyl pyrophosphate synthase.
    Type: Application
    Filed: October 12, 2021
    Publication date: April 4, 2024
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Gabriel Rodriguez, Nathan W. Schmidt, Michelle Spencer
  • Publication number: 20240102024
    Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
    Type: Application
    Filed: November 30, 2023
    Publication date: March 28, 2024
    Inventors: Dylan Alexander Carlin, Vincent M. Isabella, Jonathan McMurry, Theodore Carlton Moore, III, Mylene Perreault, Nathan Schmidt, Mark Simon
  • Patent number: 11859189
    Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: January 2, 2024
    Assignees: Synlogic Operating Company, Inc., Ginkgo Bioworks, Inc.
    Inventors: Dylan Alexander Carlin, Vincent M. Isabella, Jonathan McMurry, Theodore Carlton Moore, III, Mylene Perreault, Nathan Schmidt, Mark Simon
  • Publication number: 20230137139
    Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
    Type: Application
    Filed: March 26, 2021
    Publication date: May 4, 2023
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Kim Cecelia Anderson, Jeffrey lan Boucher, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Gabriel Rodriguez, Michelle Spencer
  • Publication number: 20230063093
    Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
    Type: Application
    Filed: August 11, 2022
    Publication date: March 2, 2023
    Inventors: Dylan Alexander Carlin, Vincent M. Isabella, Jonathan McMurry, Theodore Carlton Moore, III, Mylene Perreault, Seth Ritter, Nathan Schmidt, Mark Simon
  • Publication number: 20220362311
    Abstract: The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding an improved leucine catabolism enzyme with higher activity and/or specificity for leucine over other branched chain amino acids, such as isoleucine or valine.
    Type: Application
    Filed: June 19, 2020
    Publication date: November 17, 2022
    Inventors: Ning Li, Jian-Rong Gao, Philippa Jane Reeder Morrison, Christopher George Bergeron, Dylan Alexander Carlin, Laura K. Stone, Alex C. Tucker, Patrick M. Boyle
  • Publication number: 20220348933
    Abstract: Provided in this disclosure, in some embodiments, are methods and compositions for treating maple syrup urine disease (MSUD) and other conditions characterized by excessive branched-chain amino acids.
    Type: Application
    Filed: June 19, 2020
    Publication date: November 3, 2022
    Applicants: Ginkgo Bioworks, Inc., Synlogic Operating Company, Inc.
    Inventors: Patrick Boyle, Dylan Alexander Carlin, Rishi Jain, Ryan Putman, Laura Stone, Alex C. Tucker, Kolea Zimmerman
  • Publication number: 20220306999
    Abstract: The disclosure relates to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro comprising the use of disclosed prenyltransferase variants.
    Type: Application
    Filed: August 18, 2020
    Publication date: September 29, 2022
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Kim Cecelia Anderson, Dylan Alexander Carlin, Nicholas Flores, Katrina Forrest, Ramya L. Prathuri, Gabriel Rodriguez, Michelle Spencer
  • Publication number: 20220307060
    Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
    Type: Application
    Filed: March 9, 2022
    Publication date: September 29, 2022
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Matthew McMahon, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
  • Publication number: 20220195472
    Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
    Type: Application
    Filed: February 4, 2022
    Publication date: June 23, 2022
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
  • Patent number: 11274320
    Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: March 15, 2022
    Assignee: Ginkgo Bioworks, Inc.
    Inventors: Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
  • Publication number: 20210071209
    Abstract: Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
    Type: Application
    Filed: October 23, 2020
    Publication date: March 11, 2021
    Applicant: Ginkgo Bioworks, Inc.
    Inventors: Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Matthew McMahon, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
  • Patent number: 10200053
    Abstract: Droop caused by a filter may be compensated by applying a pre-filter to the audio signal that cancels out, at least in part, the droop caused by the filter. The pre-filter may implement magnitude compensation that causes an approximately flat passband response when the pre-filtered signal is passed through the filter. The pre-filter may be applied to one-bit wide data streams, such as high-fidelity direct stream digital (DSD) audio data or other one-bit wide data such as pulse-density modulation (PDM) encoded data. The pre-filtering and filtering may be implemented in components of an audio processor, such as in a digital-to-analog converter (DAC). The pre-filtering may include upsampling the one-bit wide data to form symbols and substituting an eighth bit of the symbol with an inverted version of an earlier-received bit.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: February 5, 2019
    Assignee: Cirrus Logic, Inc.
    Inventor: Dylan Alexander Hester
  • Patent number: 9990173
    Abstract: An audio processor may process dissimilarly formatted digital audio signals and produce an analog output for reproduction by a transducer, such as a speaker. The audio processor may be, for example, a digital-to-analog converter (DAC) with multiple digital inputs and a single analog output. The audio processor may also include other components, such as processing components, filters, equalizers, amplifiers, and the like. The audio processor may process audio, such as high fidelity DSD audio and lower fidelity PCM audio, and combine the differently formatted data into a single output. During processing, the audio processor may manipulate the different audio signals, such as by ducking a music playback to allow a notification sound to be played.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: June 5, 2018
    Assignee: Cirrus Logic, Inc.
    Inventors: Dylan Alexander Hester, Bala Vishnu Shankar Rao, Tarun Soni, John L. Melanson
  • Patent number: 9936282
    Abstract: The behavior of a NOS DAC and an analog filter may be emulated by electronic components of an integrated circuit (IC) by upsampling data and applying a digital filter to the upsampled data. For example, the IC may include a zero-order-hold circuit that upsamples data from a first input sample rate to a second, higher input rate. The upsampled data may be passed to an Asynchronous Sample Rate Converter (ASRC) that performs further upsampling (e.g., from 8*Fs-64*Fs). The upsampled data may be passed to a digital low pass filter. The digital low pass filter may emulate, for example, a response of a fifth order Butterworth analog filter to mimic the effect of analog processing. The IC may integrate the upsampling circuit, the low pass digital filter, a digital-to-analog converter (DAC) and an amplifier to provide an audio solution for playing high-fidelity music in a mobile device.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: April 3, 2018
    Assignee: Cirrus Logic, Inc.
    Inventors: Dylan Alexander Hester, Bala Vishnu Shankar Rao
  • Patent number: 9875750
    Abstract: A digital volume control may be implemented in a digital-to-analog controller (DAC) when an output rate of the DAC is higher than the input rate. The upsampling conversion process from the digital input to analog output may be controlled to adjust a volume of an output signal produced from the digital signals. The frames produced by the upsampling conversion process may include a fraction of scheduling blocks filled with the input data bit, where the fraction is based on a desired volume. The generated frames are provided to a finite impulse response (FIR) filter that produces an analog signal with a magnitude proportional to the determined fraction of scheduling blocks.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 23, 2018
    Assignee: Cirrus Logic, Inc.
    Inventors: Cory Jay Peterson, Dylan Alexander Hester
  • Publication number: 20170372717
    Abstract: A digital volume control may be implemented in a digital-to-analog controller (DAC) when an output rate of the DAC is higher than the input rate. The upsampling conversion process from the digital input to analog output may be controlled to adjust a volume of an output signal produced from the digital signals. The frames produced by the upsampling conversion process may include a fraction of scheduling blocks filled with the input data bit, where the fraction is based on a desired volume. The generated frames are provided to a finite impulse response (FIR) filter that produces an analog signal with a magnitude proportional to the determined fraction of scheduling blocks.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 28, 2017
    Applicant: Cirrus Logic International Semiconductor Ltd.
    Inventors: Cory Jay Peterson, Dylan Alexander Hester