Abstract: Among other things, embodiments of the present disclosure improve the functionality of electronic messaging systems by enabling users in an electronic chat conversation to run applications together. In some embodiments, when one user in a chat launches an application, an icon or other visual representation of the application appears in a portion of the chat window (e.g., in a “chat dock”) for other users in the chat to access.

Abstract: In one embodiment, a method includes receiving at a thermal modeling module, data from a Power Sourcing Equipment device (PSE) for cables extending from the PSE to Powered Devices (PDs), the cables configured to transmit power and data from the PSE to the PDs, calculating at the thermal modeling module, thermal characteristics for the cables based on the data, and identifying a thermal rise above a specified threshold at one of the cables. The data comprises real-time electrical data for the cables. An apparatus and logic are also disclosed herein.

Abstract: Systems and methods are provided to retrieve or analyze usage data collected from a device or a facility where the device, optionally with devices are located, and identify useful features for making a diagnosis of the device. The diagnosis can be made before a system failure to reduce down time and inefficient use of the device, or after the system failure to expedite and facilitate diagnosis and repair. In addition to the usage data, such as energy and resource consumption, the system can also obtain information relating to the facility and the device's external environment which can be used for normalizing the usage data. Further, based on the diagnosis, the system can make suitable recommendations for repair, replacement, maintenance and upgrade.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: Systems and methods are provided to retrieve or analyze usage data collected from a device or a facility where the device, optionally with devices are located, and identify useful features for making a diagnosis of the device. The diagnosis can be made before a system failure to reduce down time and inefficient use of the device, or after the system failure to expedite and facilitate diagnosis and repair. In addition to the usage data, such as energy and resource consumption, the system can also obtain information relating to the facility and the device's external environment which can be used for normalizing the usage data. Further, based on the diagnosis, the system can make suitable recommendations for repair, replacement, maintenance and upgrade.

Abstract: Systems and methods are provided to retrieve or analyze usage data collected from a device or a facility where the device, optionally with devices are located, and identify useful features for making a diagnosis of the device. The diagnosis can be made before a system failure to reduce down time and inefficient use of the device, or after the system failure to expedite and facilitate diagnosis and repair. In addition to the usage data, such as energy and resource consumption, the system can also obtain information relating to the facility and the device's external environment which can be used for normalizing the usage data. Further, based on the diagnosis, the system can make suitable recommendations for repair, replacement, maintenance and upgrade.

Abstract: Systems and methods are provided to retrieve or analyze usage data collected from a device or a facility where the device, optionally with devices are located, and identify useful features for making a diagnosis of the device. The diagnosis can be made before a system failure to reduce down time and inefficient use of the device, or after the system failure to expedite and facilitate diagnosis and repair. In addition to the usage data, such as energy and resource consumption, the system can also obtain information relating to the facility and the device's external environment which can be used for normalizing the usage data. Further, based on the diagnosis, the system can make suitable recommendations for repair, replacement, maintenance and upgrade.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.

Abstract: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.

Abstract: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.