Abstract: A utility vehicle is configured for off-road terrain and may include a plurality of mounting members configured to support a load and/or support the vehicle during transport. The utility vehicle also includes an upper frame assembly which is movable between a first position and second position. The upper frame assembly may be moved to the second position during transportation of the utility vehicle. Further, the utility vehicle includes a plurality of configurations for a rear cargo area, thereby allowing for passengers or cargo to be supported.

Abstract: Various exemplary methods and devices for actuating surgical instruments are provided. In general, a surgical device can include one or more actuation shafts configured to facilitate actuation of the device. In an exemplary embodiment, the device can include four actuation shafts, two actuation shafts to facilitate articulation of the device, one actuation shaft to facilitate opening and closing of jaws at a distal end of the device, and one actuation shaft to facilitate moving a cutting element of the device. In an exemplary embodiment, each of the one or more actuation shafts can include a distal elongate member and a proximal elongate member having a proximal end attached to a distal end of the distal elongate member. The proximal elongate member can be rigid, and the distal elongate member can be flexible.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: One or more techniques and/or systems are disclosed for a suspended center frame attached to boom wings, and coupled to a fixed center frame. A suspended center frame can be suspended from a fixed center frame with a bearing at a pivot point to allow for pivoting in multiple axes. The suspended frame can comprise one or more dampers that are operably, pivotably coupled with the fixed frame to dampen movement of the suspended frame in the roll axis; and one or more connecting links that are operably, pivotably coupled with the fixed frame to control movement of the suspended frame in the yaw and/or pitch axis. The pivot point can be located above the center of gravity of a suspended portion of the system, and proximate a top portion of the fixed frame; and the links and dampers can be disposed at a bottom portion of the suspended frame.

Abstract: The present invention relates to methods for the treatment of fibrosis. The invention discloses new research which demonstrates that interferon-lambda has directly acting anti-fibrotic effects both in vitro and in vivo and may be used to provide effective new therapies for the treatment of multiple types of fibrosis.

Abstract: A sealed terminal has a housing, a cover, a splice tray, an adapter plate, and a splice chip. The cover is connected to the housing to close an interior compartment and has input ports for receiving one or more cables and an output adapter module having a plurality of distribution ports. The splice tray is positioned in the interior compartment and has one or more cable retainers configured to route the one or more cables within the interior compartment. The adapter plate is connected to the splice tray and has a plurality of adapters for connecting the one or more cables to the distribution ports. The splice chip is connected to the splice tray and has a plurality of slots for receiving and routing the one or more cables. The housing includes a radiused wall for routing the cables within the interior compartment without bending the cables.

Abstract: The instant disclosure is generally directed to low viscosity, low volatility lubricating compositions. The lubricating composition of the instant disclosure includes an oil of lubricating viscosity that contains a lubricating base oil and a hydrocarbon oil. The hydrocarbon oil makes up least 20 wt % of the oil of lubricating viscosity and has a kinematic viscosity of less than 3.7 c St at 100° C. and a NOACK volatility (measured by ASTM D5800) of less than 25 wt %. The lubricant composition further includes a polyalkenyl succinimide dispersant, and, optionally, other formulation additives. The lubricating compositions have been shown to increase fuel economy in internal combustion engines.

Abstract: A strap system comprising a first strap extending between a first end and a second end. The first end is connected to a first attachment mechanism. The strap system further comprises a second strap extending between a third end and a fourth end. The fourth end is connected to a second attachment mechanism. The strap system comprises a load transmission device connected to the second end of the first strap and to the third end of the second strap. The load transmission device is arranged to transmit a signal in response to a tension force in the first and second straps falling below a threshold force.

Abstract: The embodiments include an array in intimate adjacent contact with a substrate foundation. The array has a plurality of radio frequency (RF) witness films overlain on the substrate foundation. Each RF witness film is a unit cell defined in a three-dimensional coordinate frame of reference, and is centered at an origin of the three-dimensional coordinate frame of reference. Each RF witness film in the plurality of RF witness films is equally-spaced from adjacent RF witness films.

Abstract: The medication dispensing assembly includes a housing having an interior. A medication bottle is disposed in the interior with its cap assembly facing vertically downwardly. The cap assembly includes outer, middle, and inner pieces. The outer and inner pieces are fixed with one another, and the middle piece is fixed with the bottle. A drive unit is disposed in the interior of the housing and is configured to rotate the bottle and the middle piece of the cap assembly about a vertical axis. The three pieces of the cap assembly have respective medication openings, and rotating the bottle causes individual pills to travel first from the bottle into the inner piece, then into the middle piece, then around the vertical axis, and then outside of the cap assembly through the medication opening of the outer piece.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: A system and method for a procedure that can be performed on an appropriate subject. A procedure may be planned, at least in part, prior to performing the procedure. An image may illustrate at least a portion of the planned procedure for confirmation and/or alteration of the planned procedure prior to performing the procedure.

Abstract: The present disclosure relates to methods and systems for algae cultivation including the integration of electrochemical carbonate production for enhancing algae growth. More particularly, the present disclosure relates to methods and systems for producing a sodium hydroxide from brine using an electrochemical cell, contacting the sodium hydroxide stream with a CO2 gas sweep and producing a carbonate stream, and cultivating an algae slurry in a cultivation vessel comprising at least a portion of the carbonate stream.

Abstract: A thermal-mechanical linear actuator can include a first stage comprising one of a positive coefficient of thermal expansion (“CTE”) material or a negative CTE material and a second stage comprising the other of the positive CTE material or the negative CTE material. The second stage can be at least partially inserted into the first stage. The actuator can further comprise a thermal isolator disposed between the first stage and the second stage to thermally isolate the first stage from the second stage. Heat inputs can be provided where the heat inputs can control the temperature of the first and second stages independently. A hyperbolic meta material can be wrapped or coated around the first stage.

Abstract: Aspects of the subject technology provide improved techniques for determining a state of an audio device, including reduced power techniques for determining if an earbud is currently being worn in a user's ear or not. In aspects, a potential state change in an audio device may be detected, and in response measurement of the state of the device may be initiated, such as by emitting an audio signal and then determining the state of the audio device based on a sensed version of the emitted audio signal.

Abstract: A head-mounted display may include a display system and an optical system in a housing. The display system may have displays that produce images. Positioners may be used to move the displays relative to the eye positions of a user's eyes. An adjustable optical system may include tunable lenses such as tunable cylindrical liquid crystal lenses. The displays may be viewed through the lenses when the user's eyes are at the eye positions. A sensor may be incorporated into the head-mounted display to measure refractive errors in the user's eyes. The sensor may include waveguides and volume holograms, and a camera for gathering light that has reflected from the retinas of the user's eyes. Viewing comfort may be enhanced by adjusting display positions relative to the eye positions and/or by adjusting lens settings based on the content being presented on the display and/or measured refractive errors.

Abstract: A surgical robotic system is disclosed to include an operating table, a plurality of robotic arms and surgical instruments, a user console, and a control tower. The plurality of robotic arms are mounted on the operating table and can be stowed folded under the table for storage. The user console has one or more user interface devices, which function as master devices to control the plurality of surgical instruments.

Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.