Patents by Inventor E. Ann Hallinan

E. Ann Hallinan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
    Patent number: 5677296
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E.sub.2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 14, 1997
    Assignee: G.D. Searle & Co.
    Inventors: Robert Alan Chrusciel, Timothy Joseph Hagen, E. Ann Hallinan, Jinglin Li, Sofya Tsymbalov, David B. Reitz
  • Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia
    Patent number: 5576315
    Abstract: The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: November 19, 1996
    Assignee: G.D. Searle & Co.
    Inventors: E. Ann Hallinan, Timothy J. Hagen, Robert K. Husa, Sofya Tsymbalov, Jean-Pierre Van Hoeck, Albert C. Lee
  • Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyn oate
    Patent number: 5536869
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof which comprises treating (trimethylsilyl)acetylene sequentially with n-butyllithium and 4-formylmorpholine followed by acid hydrolysis to give 3-(trimethylsilyl)-2-propynal; treating 3-(trimethylsilyl)-2-propynal with lithium bis(trimethylsilyl)amide to give in situ N,3-bis(trimethylsilyl)-2-propyn-1-imine; condensation of N,3-bis(trimethylsilyl)-2-propyn-1-imine with lithium t-butyl acetate to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate; treating (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate- with p-toluenesulfonic acid to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate, mono p-toluenesulfonic acid salt, treatment of resulting salt with ethanol in the presence of p-toluenesulfonic acid to give (.+-.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: July 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. McLaughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl
  • Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
    Patent number: 5488046
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E.sub.2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: January 30, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Robert A. Chrusciel, Timothy J. Hagen, E. Ann Hallinan, Jinglin Li, Sofya Tsymbalov, David B. Reitz
  • Substituted dibenzoxapine compounds, pharmaceutical compositions and methods of use
    Patent number: 5464830
    Abstract: The present invention provides dibenzoxazepine compounds, of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: November 7, 1995
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Timothy J. Hagen, Robert K. Husa, Sofya Tsymbalov, Albert C. Lee, Jean-Pierre Van Hoeck
  • 1-,2-,3-,4-,5-,6-,7-,8-, and/or 9-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
    Patent number: 5461046
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: October 24, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, Michael F. Rafferty, Timothy J. Hagen, E. Ann Hallinan
  • 10,11-dihydro-10-(3-substituted-1-oxo-2-propyl, propenyl or propynyl)dibenz[b,f][1,4] oxazepine prostaglandin antagonists
    Patent number: 5449673
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: September 12, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Nizal S. Chandrakumar, Timothy J. Hagen, E. Ann Hallinan, Robert K. Husa
  • 2-,3-,5-, and/or 8-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
    Patent number: 5449674
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: September 12, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Timothy J. Hagen, Nizal S. Chandrakumar, E. Ann Hallinan, Shashidhar N. Rao, Barnett S. Pitzele
  • 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
    Patent number: 5395932
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## wherein X is oxygen, sulfur ##STR2## A is --CH.sub.2 -- or ##STR3## E and F may be --CH, oxygen, nitrogen or sulfur, and may not be the same; G is oxygen, nitrogen or sulfur; with the proviso that when G is oxygen or sulfur, one of E or F is nitrogen, which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E.sub.2 antagonists for the treatment of prostaglandin-E.sub.2 mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin-E.sub.2 mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: March 7, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Nizal S. Chandrakumar, Timothy J. Hagen, Barnett S. Pitzele, Sofya Tsymbalov, E. Ann Hallinan
  • Substituted dibenzoxazepine compounds for the treatment of convulsions, ischemia and other diseases responsive to prostaglandin-E.sub.2 antagonists
    Patent number: 5393747
    Abstract: The present invention provides methods for treating convulsions, ischemia and other diseases responsive to prostaglandin-E.sub.2 antagonists in an animal comprising administering a therapeutically-effective amount of a substituted dibenzoxazepine compound of Formula I, or a pharmaceutically-acceptable salt thereof, to the animal: ##STR1## wherein Y is oxygen, sulfur, --SO-- or --SO.sub.2 --, R.sup.1 is hydrogen, halogen or --CF.sub.3, R.sup.2 is hydrogen, halogen, --OH or --OCH.sub.3, R.sup.3 is hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl, m is an integer of from 1 to 5, X is ##STR2## R.sup.4 is hydrogen, alkyl, aryl, alkyl-substituted aryl, trifluoromethyl-substituted aryl or aryl-substituted alkyl, and R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: February 28, 1995
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Robert K. Husa, Karen B. Peterson
  • Methods for treating convulsions and ischemia with substituted dibenzoxazepine compounds
    Patent number: 5382578
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and for the treatment of convulsions and ischemia, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain and for the treatment of convulsions and ischemia, in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: January 17, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, Timothy J. Hagen, E. Ann Hallinan
  • Substituted dibenzoxazepine compounds
    Patent number: 5378840
    Abstract: The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: January 3, 1995
    Assignee: G. D. Searle & Co.
    Inventors: Albert C. Lee, E. Ann Hallinan, Timothy J. Hagen, Robert K. Husa, Sofya Tsymbalov, Jean-Pierre Van Hoeck
  • 2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
    Patent number: 5324722
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: May 7, 1993
    Date of Patent: June 28, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Timothy J. Hagen, Michael Clare, Michael F. Rafferty, E. Ann Hallinan
  • 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
    Patent number: 5304644
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: April 15, 1992
    Date of Patent: April 19, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, Michael F. Rafferty, Timothy J. Hagen, E. Ann Hallinan
  • 8-substituted-dibenz [b,f] [1,4] oxazepine-10(11)-carboxylic acid, substituted hydrazides for the treatment of osteoporosis
    Patent number: 5283240
    Abstract: The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound of Formula I: ##STR1##
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: February 1, 1994
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Robert K. Husa, Karen B. Peterson
  • 2-H and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides for the treatment of osteoporosis
    Patent number: 5281590
    Abstract: The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound of Formula I: ##STR1##
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: January 25, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, E. Ann Hallinan, Marc Herin, Michel Lesne
  • Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
    Patent number: 5212169
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: May 18, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, Timothy J. Hagen, E. Ann Hallinan
  • 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
    Patent number: 5182272
    Abstract: The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## wherein X is ##STR2## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: January 26, 1993
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Robert K. Husa, Karen B. Peterson
  • 2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
    Patent number: 5180720
    Abstract: The present invention provides 2-, 3-, and 5- and/or 8-substituted, and/or side-chain substituted, dibenzoxazepine compounds of Formula I: ##STR1## wherein Y is sulfur, ##STR2## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: January 19, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, E. Ann Hallinan, Michel Lesne, Marc Herin
  • Sarcosine.sup.1 dehydroalanine.sup.8 angiotensin II derivatives
    Patent number: 4204991
    Abstract: The sarcosine.sup.1 dehydroalanine.sup.8 angiotensin II derivatives of the present invention are potent angiotensin blockers.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: May 27, 1980
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Robert H. Mazur