Patents by Inventor E-Chiang Lee

E-Chiang Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9783593
    Abstract: The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: October 10, 2017
    Assignee: Kymab Limited
    Inventors: Allan Bradley, Glenn Friedrich, E-Chiang Lee, Mark Strivens, Nicholas England
  • Patent number: 9783618
    Abstract: The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: October 10, 2017
    Assignee: Kymab Limited
    Inventors: Glenn Friedrich, E-Chiang Lee, Jasper Clube, Nicholas England
  • Publication number: 20170275611
    Abstract: The invention relates to an approach for introducing one or more desired insertions and/or deletions of known sizes into one or more predefined locations in a nucleic acid (e.g., in a cell or organism genome). They developed techniques to do this either in a sequential fashion or by inserting a discrete DNA fragment of defined size into the genome precisely in a predefined location or carrying out a discrete deletion of a defined size at a precise location. The technique is based on the observation that DNA single-stranded breaks are preferentially repaired through the HDR pathway, and this reduces the chances of indels (e.g., produced by NHEJ) in the present invention and thus is more efficient than prior art techniques. The invention also provides sequential insertion and/or deletions using single- or double-stranded DNA cutting.
    Type: Application
    Filed: May 31, 2017
    Publication date: September 28, 2017
    Applicant: Kymab Limited
    Inventors: Allan BRADLEY, Hanif Ali, E-Chiang Lee
  • Publication number: 20170135327
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: April 1, 2016
    Publication date: May 18, 2017
    Inventors: E-Chiang LEE, Jasper CLUBE, Allan BRADLEY
  • Publication number: 20170105396
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 20, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG
  • Publication number: 20170101482
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Glenn FRIEDRICH
  • Publication number: 20170099816
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Anais LEGENT, Ian KIRBY
  • Publication number: 20170099815
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Glenn FRIEDRICH
  • Publication number: 20170099817
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 13, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG
  • Publication number: 20170101483
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Wei WANG, Qi LIANG, Dominik SPENSBERGER, Hui LIU, Jasper CLUBE
  • Publication number: 20170096498
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 6, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Wei WANG, Qi LIANG, Dominik SPENSBERGER, Hui LIU, Jasper CLUBE
  • Publication number: 20170094956
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 6, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Anais LEGENT, Ian KIRBY
  • Publication number: 20170081423
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 5, 2016
    Publication date: March 23, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Dominik SPENSBERGER, Hui LIU, Jasper CLUBE
  • Publication number: 20170071174
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Wei WANG, Qi LIANG, Anais LEGENT, Ian KIRBY
  • Publication number: 20170051045
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: August 30, 2016
    Publication date: February 23, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Glenn FRIEDRICH
  • Publication number: 20160353719
    Abstract: The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain expression has been inactivated.
    Type: Application
    Filed: June 30, 2016
    Publication date: December 8, 2016
    Inventors: Glenn Friedrich, E-Chiang Lee
  • Publication number: 20160345552
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: August 9, 2016
    Publication date: December 1, 2016
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Glenn Friedrich
  • Publication number: 20160345551
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: July 20, 2016
    Publication date: December 1, 2016
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Anais LEGENT, Ian KIRBY
  • Patent number: 9505827
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: November 29, 2016
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Glenn Friedrich
  • Patent number: 9504236
    Abstract: The invention pertains to a transgenic non-human mammal which contains a chimeric immunoglobulin locus containing human variable region gene segments at an endogenous Ig locus operatively linked to non-human mammalian constant region genes, and methods to produce chimeric antibodies therefrom.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: November 29, 2016
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang