Patents by Inventor E. David Leonardo
E. David Leonardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7919588Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: GrantFiled: May 1, 2008Date of Patent: April 5, 2011Assignee: The Regents of the University of CaliforniaInventors: Marc Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20080241857Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: May 1, 2008Publication date: October 2, 2008Applicant: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 7041806Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: GrantFiled: September 27, 2002Date of Patent: May 9, 2006Assignee: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20030059859Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: September 27, 2002Publication date: March 27, 2003Inventors: Marc Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Publication number: 20030040046Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: ApplicationFiled: August 20, 2001Publication date: February 27, 2003Inventors: Marc Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 6277585Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.Type: GrantFiled: May 7, 1999Date of Patent: August 21, 2001Assignee: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu
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Patent number: 5939271Abstract: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceuticai industry.Type: GrantFiled: February 19, 1997Date of Patent: August 17, 1999Assignee: The Regents of the University of CaliforniaInventors: Mark Tessier-Lavigne, E. David Leonardo, Lindsay Hinck, Masayuki Masu, Kazuko Keino-Masu