Patents by Inventor E. Dilip De Silva

E. Dilip De Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimitotic eleuthesides
    Patent number: 7067494
    Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: June 27, 2006
    Assignee: The University of British Columbia
    Inventors: Raymond J. Andersen, Michel Roberge, Robert A. Britton, E. Dilip De Silva
  • Antimitotic eleuthesides
    Publication number: 20040266700
    Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.
    Type: Application
    Filed: April 7, 2004
    Publication date: December 30, 2004
    Inventors: Raymond J Andersen, Michel Roberge, Robert A. Britton, E. Dilip De Silva
  • Biologically active thiazine
    Patent number: 5106969
    Abstract: 5-Methylimidazo[4,5-e]-1,2-thiazin-4(5-H)-one, having the structure ##STR1## a cytotoxic metabolite of the marine sponge Neamphius huxleyi, has been isolated from the sponge by extraction and chromatography.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: April 21, 1992
    Assignees: Cornell Research Foundation, Inc., The University of Alberta, The University of British Columbia
    Inventors: Raymond J. Andersen, Theresa M. Allen, E. Dilip de Silva, Julie S. Racok, Jon Clardy, Linda S. Brinen