Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: The present invention is directed to compounds of formulae (I) and (II) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: Some embodiments provide a media compositing method that performs automated processes (1) to analyze the media content pieces (MCPs) to define one or more MCP groups, and (2) produces a user interface (UI) layout that identifies the defined MCP groups as groups for which the method can display composite presentations (e.g., video presentations). To define the MCP groups, the method of some embodiments uses one or more media grouping templates (MGTs). In some embodiments, the method can define multiple MGT instances for an MGT. For instance, in some embodiments, the MGTs include (1) location-bounded MGTs (e.g., videos and/or photos captured within a region with a particular radius), (2) time-bounded MGTs (e.g., videos and/or photos captured within a particular time range and/or date range), (3) time-bounded and location-bounded MGTs (e.g., mornings at a beach), (4) content-defined MGTs (e.g., videos and/or photos containing smiles), and (5) user-metadata based MGTs (e.g.

Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: A portable negative pressure wound therapy system includes a dressing assembly for positioning over a wound to apply a negative pressure to the wound and a canister assembly. The canister assembly includes a control unit having a vacuum source and a controller and a collection canister in communication with the dressing assembly operable to receive fluid from the wound. The collection canister has a filter assembly having a filter and a passageway between the filter and a wall of the collection canister. The collection canister also includes a canister interface having a suction port, an inlet port, and a channel. The vacuum source draws air through the suction port from the channel which draws air from the passageway connected to the channel, the air in the passageway is drawn from the collection canister through the filter, and the air in the collection canister is drawn through the inlet port.

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: A system and process for generalizing an evolutionary process applied to a particular domain involving different problems includes a researcher module for generating a configuration specification applicable to a particular problem. An evolution module parses the configuration specification into a representative tree structure, assembles policies for each node in the tree structure, and generates candidate genomes using the policies for each node in the tree structure. The policies may be applied to new data or data from prior runs to generate candidate genomes. The evolution module translates internal representations of the generated candidate genomes into known representations of the candidate genome for evaluation in accordance with the particular domain parameters by a candidate evaluation module.

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: Described herein is a process which facilitates segmented security between domain-specific data sets being evaluated as part of a candidate evaluation service and third-party evolution services, wherein the data sets are not transmitted to the evolution service which is evolving candidates for evaluation. This enables customers with secure data sets to use candidate evolution services securely by obtaining a population of potentially optimal candidate models to evaluate and then optimizing on those data sets in their own secure fashion.

Abstract: Disclosed herein are devices, designs, and methods of attaching an antenna to a utility meter faceplate. The faceplate is capable having an antenna adhesively attached to a side surface of the faceplate in a manner that minimizes noise from meter components.

Abstract: The invention relates generally to compounds that modulate the activity of TGF?R-1 and TGF?R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: Roughly described, a computer-implemented evolutionary data mining system includes a memory storing a candidate gene database in which each candidate individual has a respective fitness estimate; a gene pool processor which tests individuals from the candidate gene pool on training data and updates the fitness estimate associated with the individuals in dependence upon the tests; and a gene harvesting module for deploying selected individuals from the gene pool, wherein the gene pool processor includes a competition module which selects individuals for discarding in dependence upon their updated fitness estimate. The system maintains the ancestry count for each of the candidate individuals, and may use this information to adjust the competition among the individuals, to adjust the selection of individuals for further procreation, and/or for other purposes.

Abstract: The invention relates generally to compounds that modulate the activity of TGF?R-1 and TGF? R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Abstract: The invention relates generally to compounds that modulate the activity of TGFBETA R-1 and TGFBETA R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Abstract: Roughly described, a computer-implemented evolutionary data mining system includes a memory storing a candidate gene database in which each candidate individual has a respective fitness estimate; a gene pool processor which tests individuals from the candidate gene pool on training data and updates the fitness estimate associated with the individuals in dependence upon the tests; and a gene harvesting module for deploying selected individuals from the gene pool, wherein the gene pool processor includes a competition module which selects individuals for discarding in dependence upon their updated fitness estimate. The system maintains the ancestry count for each of the candidate individuals, and may use this information to adjust the competition among the individuals, to adjust the selection of individuals for further procreation, and/or for other purposes.

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: A portable negative pressure wound therapy system includes a dressing assembly for positioning over a wound to apply a negative pressure to the wound and a canister assembly. The canister assembly includes a control unit having a vacuum source and a controller and a collection canister in communication with the dressing assembly operable to receive fluid from the wound. The collection canister has a filter assembly having a filter and a passageway between the filter and a wall of the collection canister. The collection canister also includes a canister interface having a suction port, an inlet port, and a channel. The vacuum source draws air through the suction port from the channel which draws air from the passageway connected to the channel, the air in the passageway is drawn from the collection canister through the filter, and the air in the collection canister is drawn through the inlet port.